NCT07202039NARecruiting
Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine
Prisma Health-Upstate
Start Date
4/29/2026
Completion Date
6/29/2029
Summary
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine
Eligibility Criteria
Age Range: 21 years to No maximum
Inclusion Criteria
* Age ≥21 years
* Smoke ≥5 CPD for ≥1 year
* Daily CC smoker
* Willing to switch to EC
* Exhaled CO ≥6 ppm
* Diagnosed with OUD
* Stable on bupropion treatment
* In good physical and mental health
* Able to use a smartphone
* Willing to participate in all study components
* Able to provide informed consent Exclusion Criteria
* Interested in quitting CC (contemplation stage of change)
* Use of EC on ≥4 of the past 30 days
* Use of other tobacco products (e.g., cigars, smokeless tobacco) on ≥9 days of the past 30 days
* Use of nicotine replacement therapy, smoking cessation medication, or a cessation attempt in the past 30 days
* Hypertension
* Medical condition that would contraindicate participation
* Meet DSM-V criteria for major depressive episode, psychotic episode, or manic episode
* Current suicidal ideation or suicide attempt in the past year
* Psychiatric hospitalization in the past year
* Contemplating pregnancy, currently pregnant, or breastfeeding
* Unable to speak and/or read English
Interventions
BEHAVIORAL
Brief individual counseling sessions
Conditions
Tobacco-flavored ECSweet-Cooling ECSweet Non-cooling EC
Locations
Addiction Medicine Center
Greenville, South Carolina 29605
United States