NCT07206602NARecruiting

AI-Guided Left Bundle Branch Area Pacing

Mayo Clinic

Start Date

1/23/2026

Completion Date

11/1/2027

Summary

The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria * Age: 18 years or older. * Left Ventricular Ejection Fraction (LVEF): \<50% within 6 months prior to enrollment. * QRS Duration: Resting QRS duration ≥ 130 ms on ECG OR anticipated right ventricular pacing \> 40% OR device in place with right ventricular pacing \> 40% within 6 months prior to enrollment. * Medical Therapy: Optimized on guideline-directed medical therapy for heart failure. * AI-ECG probability of low LVEF: \>0.5 Exclusion Criteria * Age less than 18 years old * Inability to follow-up * Pregnancy

Interventions

DEVICE

AI-assisted Left Bundle Branch Area Pacing

PROCEDURE

Left Bundle Branch Area Pacing

Interested in This Trial?

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Conditions

Heart Failure

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States