Back to Trials
NCT07209488NARecruiting

Acquired Dyslexia Modeling and Treatment

Rutgers, The State University of New Jersey

Start Date

12/3/2025

Completion Date

9/1/2026

Summary

This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.

Eligibility Criteria

Age Range: 18 years to 85 years

Inclusion Criteria: * Fluent in English as a first language pre-stroke by self report. * Normal or corrected-to-normal vision. * Normal or aided hearing. * Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan). * Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III. Exclusion Criteria: * Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke. * Severe apraxia of speech (determined by consensus judgment among speech-language pathologists). * History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders. * Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.

Interventions

BEHAVIORAL

Phono-Motor Therapy

BEHAVIORAL

Semantic Feature Analysis

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

StrokeDyslexia, Acquired

Locations

Florida State University

Tallahassee, Florida 32306

United States

Johns Hopkins University School of Medicine

Baltimore, Maryland 21287

United States

Kessler Foundation

West Orange, New Jersey 07052

United States