NCT07218471NARecruiting

Cannabis Reduction and Functional Outcomes

Medical University of South Carolina

Start Date

3/13/2026

Completion Date

1/30/2030

Summary

This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in urinary cannabinoids. The study aims to assess improvements in cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Age 18+ * Urinary cannabinoid level ≥ 50 ng/mL * DSM-5 diagnosis of CUD (mild, moderate, or severe) * Willingness to attempt cannabis reduction * Completion of Intake Visit Exclusion Criteria: * Serious medical/psychiatric conditions * Pregnancy or breastfeeding * Use of cannabis in past 30 days was for medical purposes only * Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition * Cognitive or understanding difficulties, as evidenced by inability to pass informed consent quiz

Interventions

BEHAVIORAL

CBT4CBT (Computerized Cognitive Behavioral Therapy)

BEHAVIORAL

Motivational Interviewing

BEHAVIORAL

Contingency Management

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Conditions

Cannabis Use Disorder

Locations

Medical University of South Carolina

Charleston, South Carolina 29425

United States