NCT07218601PHASE2Recruiting
Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
Start Date
10/10/2025
Completion Date
10/1/2027
Summary
The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure changes in certain chemicals in the breath before and after standard neoadjuvant therapy in people with NSCLC.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Age ≥18
* Untreated clinical stage I NSCLC amenable to upfront surgery
* Untreated stage II to IIIB NSCLC amenable to neoadjuvant treatment followed by surgery
* ECOG Performance Status of ≤2 Of note, the E-nose is a completely noninvasive technology (only breath samples are collected). Therefore, this intervention would have no effects on a developing human fetus. There are therefore no requirements for the study population related to contraception or pregnancy testing.
Interventions
DIAGNOSTIC_TEST
Breath sample collection
DIAGNOSTIC_TEST
Research blood collection
Conditions
Non-Small Cell Lung Cancer
Locations
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey 07920
United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey 07645
United States
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York 10065
United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, New York 11553
United States