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NCT07218601PHASE2Recruiting

Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

Start Date

10/10/2025

Completion Date

10/1/2027

Summary

The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure changes in certain chemicals in the breath before and after standard neoadjuvant therapy in people with NSCLC.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Age ≥18 * Untreated clinical stage I NSCLC amenable to upfront surgery * Untreated stage II to IIIB NSCLC amenable to neoadjuvant treatment followed by surgery * ECOG Performance Status of ≤2 Of note, the E-nose is a completely noninvasive technology (only breath samples are collected). Therefore, this intervention would have no effects on a developing human fetus. There are therefore no requirements for the study population related to contraception or pregnancy testing.

Interventions

DIAGNOSTIC_TEST

Breath sample collection

DIAGNOSTIC_TEST

Research blood collection

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Conditions

Non-Small Cell Lung Cancer

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey 07920

United States

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey 07748

United States

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey 07645

United States

Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)

Commack, New York 11725

United States

Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York 10604

United States

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York 10065

United States

Memorial Sloan Kettering Nassau (All Protocol Activities)

Uniondale, New York 11553

United States