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NCT07219030PHASE1RecruitingAccepts Healthy Volunteers

A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

AbbVie

Start Date

10/8/2025

Completion Date

3/1/2027

Summary

This study is to assess how oral emraclidine moves through the body of healthy elderly adult participants, and assess adverse events, and tolerability.

Eligibility Criteria

Age Range: 65 years to 85 years

Inclusion Criteria: * BMI is ≥ 18.0 to ≤ 32.0 kg/m2 after rounding to the tenths decimal at Screening. BMI is calculated as weight in kg divided by the square of height measured in meters. * Body weight \> 45 kg at the time of screening and upon initial confinement. * A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead ECG. Exclusion Criteria: * History of any clinically significant cardiac, respiratory (except mild asthma as a child), renal, hepatic, gastrointestinal, genitourinary, immunological, hematologic, neurological or psychiatric disease or disorder, or any other uncontrolled medical illness. * History of any clinically significant sensitivity or allergy to any medication or food. * Evidence of dysplasia or history of malignancy (including lymphoma and leukemia) other than successfully treated non-metastatic cutaneous squamous cell, basal cell carcinoma or localized carcinoma in situ of the cervix.

Interventions

DRUG

Emraclidine

DRUG

Placebo

Interested in This Trial?

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Conditions

Healthy Volunteer

Locations

Altasciences Clinical Los Angeles /ID# 276854

Cypress, California 90630

United States

K2 Medical Research, LLC /ID# 276636

Maitland, Florida 32751

United States

Clinical Pharmacology Of Miami /ID# 276856

Miami, Florida 33172

United States

Acpru /Id# 276996

Grayslake, Illinois 60030

United States