NCT07221617PHASE4Recruiting

Oral Methadone in Cardiac Surgery

Mayo Clinic

Start Date

1/13/2026

Completion Date

8/1/2026

Summary

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: • Undergoing elective cardiac surgery Exclusion Criteria: * Chronic pain requiring opioid medications as an outpatient * Opioid use disorder on medication assistance treatment * Prolonged QTc \>500ms * Chronic kidney disease with eGFR \< 30mL/min * Documented cirrhosis * Intolerance to methadone * Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery * Pregnancy at the time of surgery * Subsequent surgeries after index surgery

Interventions

DRUG

Methadone, oral

DRUG

Methadone, intravenously

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Pain, PostoperativeAnesthesiaCardiac Surgery

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States