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NCT07222280NARecruiting

Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy

Covenant Health, US

Start Date

6/10/2025

Completion Date

3/31/2026

Summary

The goal of this clinical trial is to determine if utilizing the Quest AD-Detect blood test, while patient's are hospitalized for a cognitive diagnosis (such as delirium or encephalopathy), will result in an earlier diagnosis of underlying Alzheimer's disease. * Will this blood test have the ability to distinguish between Alzheimer's disease and other causes of cognitive impairment in the inpatient setting? * Neurology Clinic will complete a 6-month post-hospitalization follow up with patients who have had the Quest AD-Detect Alzheimer's Disease blood test completed while they were inpatient to discuss the risk assessment portfolio

Eligibility Criteria

Age Range: 60 years to 90 years

Inclusion Criteria: * Ages 60 to 90 years old * No prior diagnosis of dementia * Currently hospitalized with cognitive diagnosis, including but no limited to; delirium, encephalopathy, etc. thought to be secondary to a toxic/metabolic state Exclusion Criteria: * Age under 60 years * Prior diagnosis of dementing illness or other organic etiology to cognitive impairment

Interventions

DIAGNOSTIC_TEST

Quest AD-Detect blood test

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Conditions

Alzheimer DementiaAlzheimer DiseaseDelirium Confusional StateEncephalopathyCognitive Abnormality

Locations

Cumberland Medical Center

Crossville, Tennessee 38555

United States

Roane Medical Center

Harriman, Tennessee 37748

United States

Fort Sanders Regional Medical Center

Knoxville, Tennessee 37916

United States

Fort Loudon Medical Center

Lenoir City, Tennessee 37772

United States

Methodist Medical Center

Oak Ridge, Tennessee 37830

United States

LeConte Medical Center

Sevierville, Tennessee 37862

United States