NCT07225777PHASE2Recruiting

Sex Differences in Neurobehavioral Response to THC

Medical University of South Carolina

Start Date

4/27/2026

Completion Date

12/31/2027

Summary

This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).

Eligibility Criteria

Age Range: 21 years to 45 years

Inclusion Criteria: * Age 21-45 * DSM-5 criteria for CUD * Cannabis use ≥4 days/week * THC-positive urine * BMI 18-30 * Regular menstrual cycle (females) * Willingness to use non-hormonal birth control (females) Exclusion Criteria: * Lifetime psychotic or bipolar disorder * Recent drug use other than cannabis * Current psychotropic medication * Treatment-seeking for SUD * Current psychiatric disorder (except mild alcohol, nicotine, or caffeine use disorder) * Pregnancy/nursing * MRI contraindications

Interventions

DRUG

Dronabinol

DRUG

Placebo

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Conditions

Cannabis Use Disorder

Locations

Medical University of South Carolina

Charleston, South Carolina 29403

United States