NCT07226076PHASE3Recruiting

Methadone in TKA for Post-op Pain and Opioid Reduction

Medical University of South Carolina

Start Date

1/8/2026

Completion Date

1/15/2027

Summary

This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion * Ages 18-75 years of age * Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia Exclusion * Allergy to methadone or mepivacaine * Severe liver disease defined as Child's Pugh Class C * End stage renal disease requiring dialysis * Known diagnosis of prolonged QT syndrome * Currently pregnant * Unable to provide written, informed consent * Non-English speaking

Interventions

DRUG

Methadone Hydrochloride

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Conditions

Post Operative Pain

Locations

Medical University of South Carolina

Charleston, South Carolina 29425

United States