A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
Start Date
3/3/2026
Completion Date
10/1/2027
Summary
The goal of this clinical trial is to learn how tests undertaken by people at high risk of developing psychosis (aged 17 to 30 years old) change when those people are given the study drug MT1988 daily for 8 weeks. This will help identify tests that could be used in later trials developing treatments for symptoms in people at high risk of developing psychosis, to measure whether those new treatments are effective. The main question this trial aims to answer is: Can any of the tests (biomarkers) used in this study detect changes in participants dosed with one of two different dose levels of MT1988? Researchers will compare the results from two dose levels of MT1988 to a placebo group. Researchers do not expect to see the test results change in participants taking placebo and this will be compared to changes expected in test results in participants taking MT1988. Participants will: * take a dose of MT1988 or placebo twice per day for 8 weeks * attend clinic appointments every two weeks to undertake assessments * report any side effects they experience to the researchers
Eligibility Criteria
Age Range: 17 years to 30 years
Interventions
MT1988 Low Dose
MT1988 High Dose
Placebo
Conditions
Locations
University of California, Irvine
Irvine, California 92697
United States
University of California
Los Angeles, California 90095
United States
University of California, San Francisco
San Francisco, California 94107
United States
Yale University Conneticut Mental Health Center
New Haven, Connecticut 06519
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02115
United States
Washington University
St Louis, Missouri 63110
United States
Northwell Health
Glen Oaks, New York 11004
United States
Columbia University
New York, New York 10032
United States
Icahan School of Medicine at Mount Sinai
New York, New York 10128
United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27514
United States
Ohio State University
Columbus, Ohio 43210
United States
Prevention Science Institute
Eugene, Oregon 97403
United States
University of Pennsylvania
Philadelphia, Pennsylvania 19104
United States
Temple University
Philadelphia, Pennsylvania 19122
United States
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania 15213
United States