NCT07226947NARecruiting
Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
Massachusetts General Hospital
Start Date
11/24/2025
Completion Date
6/1/2027
Summary
The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirzepatide or retatrutide), also known as glucagon-like peptide 1 receptor agonist (GLP-1 RA) medications.
Eligibility Criteria
Age Range: 18 years to 99 years
Inclusion Criteria
1. Age ≥ 18 years old at time of signing informed consent
2. Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment
a. Potential participants switching GLP1-RA therapies due to inadequate response to a prior treatment will be eligible for enrollment
3. Able to provide informed consent
Exclusion Criteria
1. Current pregnancy (positive urine hCG) or plans to become pregnant in the next 6 months
2. BMI \<25 kg/m2 at the time of screening
3. Unable to participate in a regular physical exercise program
4. Implanted pacemaker
5. Any factors that, in the opinion of the principal investigator, would interfere with the safe completion of the study
Interventions
DEVICE
Smartwatch activity and body composition monitor
BEHAVIORAL
General guidance on recommended exercise
Conditions
ObesityBody Composition
Locations
Diabetes Research Center
Boston, Massachusetts 02114
United States