NCT07234032PHASE3Recruiting
An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Insmed Incorporated
Start Date
7/20/2026
Completion Date
1/22/2031
Summary
The primary objective of this study is to evaluate the safety and tolerability of the long-term use of TPIP in participants with PH-ILD from Study INS1009-311 (NCT07179380).
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria
* Participants who have completed the lead-in PH-ILD TPIP Study INS1009-311 (NCT07179380).
* Capable of giving signed informed consent that includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
* Agree not to participate in any other interventional trials or use investigational drugs or devices while participating in the INS1009-312 study.
Exclusion Criteria
* Participants who experienced any adverse events (AEs) evaluated as causally related to TPIP by the Investigator in a lead-in study, which in the opinion of the Investigator, could pose an unreasonable risk of continued treatments for the participant.
* Current use or expected need for pulmonary arterial hypertension (PAH)-approved therapy, including prostacyclin, prostacyclin analogues or other prostacyclin receptor agonists, endothelin receptor antagonists, and/or soluble guanylate cyclase stimulator, or any PH-ILD approved treprostinil therapy. Use of phosphodiesterase 5 inhibitors in line with applicable guidelines is allowed.
* Diagnosis of Pulmonary Hypertension World Health Organisation (WHO) Groups 1, 2, 4, or 5, or subtypes of PH WHO Group 3 other than interstitial lung disease (including combined pulmonary fibrosis and emphysema).
* Evidence of left ventricular failure, heart failure with preserved ejection fraction (HFpEF) or postcapillary PH.
* Known hypersensitivity or contraindication to treprostinil or TPIP or TPIP formulation excipients (eg, mannitol, leucine).
Note: Other protocol-defined inclusion/exclusion criteria may apply.
Interventions
DRUG
Treprostinil Palmitil Inhalation Powder
DRUG
Placebo
Conditions
Pulmonary HypertensionInterstitial Lung Disease
Locations
USA006
Naples, Florida 34102
United States
USA003
Bend, Oregon 97701
United States
JPN004
Narita, Chiba 286-8520
Japan
KOR001
Seoul, 3080
South Korea
KOR006
Seoul, 6351
South Korea
ESP006
Madrid, 28041
Spain
ESP003
Madrid, 28046
Spain
ESP001
Seville, 41009
Spain
TWN003
Hsinchu, 30059
Taiwan