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NCT07242469PHASE1Recruiting

A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)

Merck Sharp & Dohme LLC

Start Date

12/22/2025

Completion Date

9/3/2026

Summary

The purpose of this study is to learn about the safety and if people tolerate a study medicine called MK-1403. The study will also measure what happens to MK-1403 in the body of a person with type 2 diabetes (T2D) over time (pharmacokinetic or PK study), and how it affects the amount of high-sensitivity C-reactive protein (hsCRP) in a person's blood.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: * Has a confirmed diagnosis of Type 2 diabetes mellitus (T2DM) * Has body mass index (BMI) between 18 and 40 kg/m\^2, inclusive Exclusion Criteria: * Has Type 1 diabetes mellitus or secondary types of diabetes * Has a history of congestive heart failure (New York Heart Association \[NYHA\] Class 3 or 4) * Has history of myocardial infarction, uncontrolled arrhythmias, cardiac revascularization, angina, unstable peripheral arterial disease and/or stroke * Has history of cancer (malignancy) * Has positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis C antibodies, or human immunodeficiency virus (HIV) * Has a history of gastrointestinal (GI) disease which might affect food and drug absorption, or has had gastric bypass or similar surgery

Interventions

DRUG

MK-1403 + additive coformulation

DRUG

Placebo + additive coformulation

Interested in This Trial?

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Conditions

Diabetes Mellitus, Type 2

Locations

Anaheim Clinical Trials ( Site 0006)

Anaheim, California 92801

United States

ProSciento Inc. ( Site 0001)

Chula Vista, California 91911

United States

Advanced Pharma CR, LLC ( Site 0003)

Miami, Florida 33147

United States

QPS-MRA, LLC ( Site 0004)

South Miami, Florida 33143

United States

Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0005)

Springfield, Missouri 65802

United States