NCT07244445NARecruitingAccepts Healthy Volunteers
Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy
Ian J. Neeland, MD
Start Date
1/29/2026
Completion Date
12/1/2027
Summary
In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.
Eligibility Criteria
Age Range: 18 years to 80 years
Inclusion Criteria:
* Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been continuously using semaglutide or tirzepatide for three months for a clinical indication and remain on the therapy at the time of enrollment
Exclusion Criteria:
* No use or contraindication to use of a GLP-1 RA
* Known allergy to nuts
* Pregnant or breastfeeding
* Incarcerated
Interventions
DIETARY_SUPPLEMENT
Pistachios
PROCEDURE
Dual-energy X-ray absorptiometry (DEXA) scans
Conditions
Dietary ChangeObesity & OverweightFood Acceptance
Locations
University Hospitals Cleveland Medical Center
Clevland, Ohio 44106
United States