NCT07246993NARecruiting

Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

University of Minnesota

Start Date

3/5/2026

Completion Date

1/1/2028

Summary

This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals suffering from persistent post-concussive syndrome (PPCS) following mild traumatic brain injury (mTBI).

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria: * Age 18-65 * Has sustained a single mTBI 3-12 months prior to enrollment * Meets criteria for PPCS (assessed using the CP Screen) * Has reliable access to a smartphone Exclusion Criteria: * Inability to provide informed consent or complete study procedures * History of moderate/severe TBI * Significant neurological or psychiatric disorders (other than PPCS-related symptoms like mild depression/anxiety) * Substance dependence within the last six months * Contraindications to tDCS (e.g., implanted metal, skin lesions on scalp)

Interventions

DEVICE

Active tDCS

DEVICE

Sham tDCS

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Conditions

Persistent Post Concussion SyndromeMild Traumatic Brain Injury

Locations

University of Minnesota

Minneapolis, Minnesota 55455

United States