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NCT07252947NARecruitingAccepts Healthy Volunteers

Stress and Anxiety Effects on Valuation

NYU Langone Health

Start Date

12/18/2025

Completion Date

11/7/2028

Summary

The purpose of this study is to understand how stress, anxiety, and negative affect change learning and decision-making processes. The primary objective is to assess two forms of decision-making-reward adaptation and emotion prediction errors-differ as a function of stress and anxiety. The secondary objectives are to assess how individual differences measured in our studies relate to these decision variables.

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria: Aims 1-3: To be eligible for participation in this study, an individual must meet all of the following criteria: * 18-65 years of age * Able to speak, read, and write fluently in English * Be willing and able to follow study procedures and provide informed consent. Aim 4: To be eligible for participation in this study, an individual must meet all of the following criteria: * 18-65 years of age * Diagnosis of GAD * Able to speak, read, and write fluently in English * Be willing and able to follow study procedures and provide informed consent. Exclusion Criteria: Aims 1-3: Individuals will be excluded from participation if any of the following criteria are met: * History of or medication for neurologic or psychiatric disease * High-blood pressure or heart condition * Diabetes, food allergies, metabolic disorders or history of eating disorder * Use of corticosteroids or beta-blockers * Pregnancy Aim 4: Individuals will be excluded from participation if any of the following criteria are met: * High-blood pressure or heart condition * Diabetes, food allergies, metabolic disorders or history of eating disorder * Use of corticosteroids or beta-blockers * Lifetime history of bipolar disorder or any psychotic disorder; substance use disorder in past 3 months; eating disorder in past 6 months; current major depressive disorder (past is allowed) * Active suicidal ideation with plan and intent (indicated by score \>=4 on the Columbia Suicide Severity Scale) * Not on stable dose of psychiatric medication for at least 4 weeks prior to study participation * Pregnancy

Interventions

BEHAVIORAL

Socially Evaluated Cold Pressor Task (SECPT)

BEHAVIORAL

Non-Stressful Control Task

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Conditions

Reward Value Level

Locations

NYU Langone Health

New York, New York 10016

United States