A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Start Date
1/22/2026
Completion Date
11/1/2031
Summary
The purpose of this study is to investigate the efficacy and safety of fixed-duration sonrotoclax (also known as BGB-11417) plus zanubrutinib (also known as BGB-3111) (SZ) compared with fixed-duration of venetoclax plus acalabrutinib (AV) in participants with previously untreated chronic lymphocytic leukemia (CLL).
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Sonrotoclax
Zanubrutinib
Acalabrutinib
Venetoclax
Conditions
Locations
City of Hope National Medical Center
Duarte, California 91010-3012
United States
Chao Family Comprehensive Cancer Center
Orange, California 92868-3201
United States
Stanford Cancer Institute
Palo Alto, California 94304-2205
United States
Rocky Mountain Cancer Centers (Williams) Usor
Aurora, Colorado 80012-5405
United States
Mayo Clinic Jacksonville
Jacksonville, Florida 32224-1865
United States
Mount Sinai Medical Center Braman Comprehensive Cancer Center
Miami, Florida 33140
United States
Moffitt Cancer Center
Tampa, Florida 33612-9496
United States
Northwestern University
Chicago, Illinois 60611
United States
Midwestern Regional Medical Center
Zion, Illinois 60099-2676
United States
Ochsner Clinic Foundation
New Orleans, Louisiana 70121-2429
United States
Dana Farber Cancer Institute
Boston, Massachusetts 02215-5418
United States
Mayo Clinic Rochester
Rochester, Minnesota 55905-0001
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
Columbia University Medical Center
New York, New York 10032
United States
Atrium Health Levine Cancer Institute (Lci)
Charlotte, North Carolina 28204-2990
United States
Duke University Medical Center
Durham, North Carolina 27705-3976
United States
Oncology Associates of Oregon Willamette Valley Cancer Center
Eugene, Oregon 97401
United States
Upmc Hillman Cancer Center(Univ of Pittsburgh)
Pittsburgh, Pennsylvania 15232-1309
United States
Texas Oncology Tyler
Tyler, Texas 75702-7522
United States
Huntsman Cancer Institute
Salt Lake City, Utah 84112-5550
United States
Fred Hutchinson Cancer Research Center
Seattle, Washington 98109-4433
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226-3522
United States
Blacktown Cancer and Haematology Centre
Blacktown, New South Wales NSW 2148
Australia
Concord Repatriation General Hospital
Concord, New South Wales NSW 2139
Australia
Genesiscare North Shore
St Leonards, New South Wales NSW 2065
Australia
Princess Alexandra Hospital
Woolloongabba, Queensland QLD 4102
Australia
Monash Health
Clayton, Victoria VIC 3168
Australia
Austin Health
Heidelberg, Victoria VIC 3084
Australia
Cabrini Hospital Malvern
Malvern, Victoria VIC 3144
Australia
The Alfred Hospital
Melbourne, Victoria VIC 3004
Australia
Instituto Dor de Pesquisa E Ensino Distrito Federal
Brasília, 70390140
Brazil
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
Porto Alegre, 90110-270
Brazil
Ensino E Terapia de Inovacao Clinica Amo Etica
Salvador, 41950-640
Brazil
Instituto Dor de Pesquisa E Ensino Sao Paulo
São Paulo, 01401-004
Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05652-900
Brazil
Bc Cancer Victoria
Victoria, British Columbia V8R 6V5
Canada
Juravinski Cancer Centre
Hamilton, Ontario L8V 5C2
Canada
Ciusss Nim Hscm
Montreal, Quebec H4J 1C5
Canada
Jewish General Hospital
Montreal, Quebec QC H3t 1E2
Canada
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
Québec, Quebec G1J 1Z4
Canada
Ciusss de Lestrie Chus
Sherbrooke, Quebec J1H 5N4
Canada
Peking Union Medical College Hospital
Beijing, Beijing Municipality 100730
China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality 630014
China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian 350005
China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong 510000
China
Sun Yat Sen University Cancer Center Huangpu Branch
Guangzhou, Guangdong 510555
China
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi 530021
China
Guizhou Provincial Peoples Hospital
Guiyang, Guizhou 550002
China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang 150000
China
Henan Cancer Hospital
Zhengzhou, Henan 450000
China
The Second Xiangya Hospital of Central South University
Changsha, Hunan 410011
China
Jiangsu Province Hospital
Nanjing, Jiangsu 210029
China
Affiliated Hospital of Nantong University
Nantong, Jiangsu 201203
China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi 330006
China
The Second Affiliated Hospital of Xian Jiaotong University
Xi'an, Shaanxi 710004
China
Shandong Provincial Hospital
Jinan, Shandong 250000
China
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality 200025
China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital
Chengdu, Sichuan 610071
China
Institute of Hematology and Hospital of Blood Disease
Tianjin, Tianjin Municipality 300020
China
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan 650032
China
The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan
Hangzhou, Zhejiang 310002
China
Fakultni Nemocnice Brno
Brno, 625 00
Czechia
Fakultni Nemocnice Hradec Kralove
Hradec Králové, 500 03
Czechia
Fakultni Nemocnice Olomouc
Olomouc, 77900
Czechia
Fakultni Nemocnice Ostrava
Ostrava, 708 00
Czechia
Fakultni Nemocnice Plzen
PLZE, 323 00
Czechia
Vseobecna Fakultni Nemocnice V Praze
Prague, 10000
Czechia
Centre de Lutte Contre Le Cancer Institut Bergonie
Bordeaux, 33076
France
Chu Clermont Ferrand Therapie Cellulaire and Hematolo
ClermontFerrand, 63100
France
Centre Hospitalier Le Mans
Le Mans, 72037
France
Hopital Claude Huriez Chu Lille
Lille, 59000
France
Centre Leon Berard
Lyon, 69373
France
Chu Montpellier Hopital Saint Eloi
Montpellier, 34090
France
Iuc Toulouse Oncopole
Toulouse, 31100
France
Donauisar Klinikum Deggendorf Klinik Fur Onkologie Und Hamatologie
Deggendorf, 94469
Germany
Centrum Fur Haematologie Und Onkologie Bethanien
Frankfurt am Main, 60389
Germany
Geho Munster
Münster, 48153
Germany
Klinikum St Elisabeth Straubing Gmbh Mvz Klinikum Straubing Gmbh
Straubing, 94315
Germany
Irccs Azienda Ospedaliero Universitaria Bologna
Bologna, 40138
Italy
Aou Careggi, Servizio Sanitario Toscana
Florence, 50134
Italy
Ospedale San Raffaele
Milan, 20132
Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, 20162
Italy
Azienda Ospedaliera Di Padova
Padova, 35128
Italy
Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168
Italy
Flevoziekenhuis
Almere Stad, 1315 RA
Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, 3318 AT
Netherlands
Hagaziekenhuis
Sgravenhage, 2545 AA
Netherlands
North Shore Hospital
Auckland, 0622
New Zealand
Auckland City Hospital
Auckland, 1023
New Zealand
Health New Zealand Canterbury
Christchurch, 8011
New Zealand
Dunedin Hospital
Dunedin, 9016
New Zealand
Wellington Regional Hospital (Ccdhb)
Wellington, 6021
New Zealand
Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny
Brzozów, 36-200
Poland
Pratia Onkologia Katowice
Katowice, 40-519
Poland
Pratia McM Krakow
Krakow, 30-727
Poland
Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie
Lublin, 20-090
Poland
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
Wroclaw, 50-367
Poland
Coltea Clinical Hospital
Bucharest, 30171
Romania
Institutul Clinic Fundeni
Bucureti, 022328
Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
ClujNapoca, 400015
Romania
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, Seoul Teugbyeolsi 06591
South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi 03722
South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi 03080
South Korea
Asan Medical Center
SongpaGu, Seoul Teugbyeolsi 05505
South Korea
Hospital Universitario Virgen de Las Nieves
Granada, 18014
Spain
Hospital Universitario 12 de Octubre
Madrid, 28041
Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, 28222
Spain
Hospital Clinico Universitario Virgen de La Arrixaca
Murcia, 30120
Spain
Karolinska Universitetssjukhuset Solna
Stockholm, 171 76
Sweden
Queen Elizabeth Hospital
Birmingham, B15 2TH
United Kingdom
University Hospitals Dorset Royal Bournemouth Hospital
Bournemouth, BH7 7DW
United Kingdom
St Jamess University Hospital
Leeds, LS9 7TF
United Kingdom
Kings College Hospital
London, SE5 9RS
United Kingdom
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Norwich, NR4 7UY
United Kingdom