NCT07279558PHASE2Recruiting

Cannabidiol and Alcohol Use Disorder Phenotypes

University of Colorado, Denver

Start Date

3/31/2026

Completion Date

8/31/2029

Summary

The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

Detailed Description

Your participation will include up to five in-person visits over about 13 weeks, including a screening visit, a visit to get your medication, a midpoint visit, an experimental lab session, and a final follow-up visit. You will be assigned to a study medication which you will take daily for 8 weeks while completing daily surveys and weekly virtual check-ins with the research team. During the experimental lab session visit, you will be offered alcohol to drink at the bar lab.

Eligibility Criteria

Age Range: 21 years to 65 years

Inclusion Criteria: 1. Age 21-65 2. Have used CBD and cannabis at least once in the last year 3. Regularly drink alcohol 4. Able to provide informed consent and attend in-person study visits Exclusion Criteria: 1. Current use of medications known to have major interaction with Epidiolex, Marinol, or alcohol 2. Current use of antiepileptic medication or any psychotropic medication besides antidepressants 3. Pregnant, nursing, or planning a pregnancy 4. Medical conditions that contraindicates the use of CBD or alcohol 5. Current medical conditions that may require intensive care during the study period Not everyone will qualify to be in the study. Other inclusion and exclusion criteria will be evaluated by the study team.

Interventions

DRUG

Full-Spectrum Cannabidiol (CBD)

DRUG

Broad-Spectrum Cannabidiol (CBD)

DRUG

Placebo

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

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Conditions

Alcohol Use Disorder

Locations

University of Colorado School of Medicine- Anschutz Medical Campus

Aurora, Colorado 80045

United States