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NCT07285863PHASE4RecruitingAccepts Healthy Volunteers

A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects

Mayo Clinic

Start Date

3/11/2026

Completion Date

3/1/2028

Summary

The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.

Eligibility Criteria

Age Range: 18 years to 80 years

Inclusion Criteria * Males or non-pregnant females * Age 18-80. * Participants must be in good health based on medical history (ASA Class 3 or below) * Participants must be willing and able to provide informed consent * Receiving an endoscopic ultrasound for a non-pancreatic indication Exclusion Criteria * History of any form of pancreatitis and/or other pancreatic diseases (e.g. pancreatic cysts, pancreatic masses). * History of inflammatory bowel disease * History of vagotomy. * History of surgically altered upper gastrointestinal anatomy (e.g. gastric bypass, Billroth I/II) * History of liver disease * Pregnant women or nursing mothers * Regular use of anticholinergics * \> 2 drinks of alcohol daily * Smokers (cigarette)

Interventions

DRUG

Secretin (human synthetic) - ChiRhoClin

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Conditions

Exocrine Pancreatic InsufficiencyChronic Pancreatitis

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States