A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
Start Date
4/30/2026
Completion Date
4/13/2032
Summary
Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread. The goals of this study are to learn: * About the safety of MK-1084 and if people tolerate it when taken with other treatments * How many people have the cancer respond (get smaller or go away) to the treatments
Detailed Description
This is a substudy of the master protocol MK-3475-U01 (KEYMAKER-U01) - NCT04165798. Per amendment 3, the MK-1084 + Cetuximab arm was discontinued.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
MK-1084
Patritumab deruxtecan
Sacituzumab tirumotecan
Cetuximab
Rescue Medications
Conditions
Locations
Clermont Oncology Center ( Site 0041)
Clermont, Florida 34711
United States
University of Illinois Hospital & Health Sciences System ( Site 0044)
Chicago, Illinois 60612
United States
Providence Portland Medical Center ( Site 0043)
Portland, Oregon 97213
United States
Providence Oncology and Hematology Care Clinic - Westside ( Site 0059)
Portland, Oregon 97225
United States
Hospital São Lucas da PUCRS ( Site 0283)
Porto Alegre, Rio Grande do Sul 90610-000
Brazil
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0282)
Barretos, São Paulo 14784-400
Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0286)
São José do Rio Preto, São Paulo 15090-000
Brazil
Hospital Paulistano ( Site 0280)
São Paulo, São Paulo 01321001
Brazil
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0162)
Santiago, Region M. de Santiago 7500653
Chile
FALP ( Site 0161)
Santiago, Region M. de Santiago 7500921
Chile
Bradfordhill ( Site 0160)
Santiago, Region M. de Santiago 8420383
Chile
Guangdong Provincial People s Hospital ( Site 0300)
Guangzhou, Guangdong 510120
China
UniversitaetsklInikum Tuebingen ( Site 0192)
Tübingen, Baden-Wurttemberg 72076
Germany
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 0204)
Athens, Attica 115 27
Greece
Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 0205)
Athens, Attica 115 28
Greece
Queen Mary Hospital ( Site 0230)
Hong Kong, 000000
Hong Kong
Hong Kong United Oncology Centre ( Site 0232)
Jordan, 000000
Hong Kong
Prince of Wales Hospital ( Site 0231)
Shatin,
Hong Kong
Shaare Zedek Medical Center ( Site 0186)
Jerusalem, 9103102
Israel
Sheba Medical Center ( Site 0180)
Ramat Gan, 5265601
Israel
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0176)
Meldola, Forli-Cesena 47014
Italy
Severance Hospital, Yonsei University Health System ( Site 0080)
Seoul, 03722
South Korea
Institut Català d'Oncologia - L'Hospitalet ( Site 0090)
Hospitalet, Barcelona 08908
Spain
Hospital Clinic de Barcelona ( Site 0092)
Barcelona, 08036
Spain
Hospital Universitario Virgen Macarena ( Site 0093)
Seville, 41009
Spain