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NCT07290036PHASE1Recruiting

A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults

UCB Biopharma SRL

Start Date

12/10/2025

Completion Date

9/14/2028

Summary

To demonstrate that bimekizumab administered intravenously is noninferior to subcutaneous administration.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: 1. Be 18+ years old and legally able to consent 2. Have active psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA), suitable for bimekizumab treatment 3. Weigh between 45-100 kg (females) or 50-100 kg (males). 4. Be biologic disease-modifying anti-rheumatic drug (bDMARD)-naïve or have stopped bDMARDs ≥3 months or 5 half-lives ago Exclusion Criteria: 1. Serious organ system disorders (e.g., heart, liver, kidney, gastrointestinal, neuro) 2. Severe psychiatric issues or substance abuse in the past year 3. Recent or chronic infections, including tuberculosis (TB) or nontuberculous mycobacterium (NTMB) 4. Other inflammatory diseases (e.g., rheumatoid arthritis (RA), lupus, inflammatory bowel disease (IBD)) 5. Recent live vaccines (within 8 weeks) or Bacillus Calmette-Guerin (BCG) (within 1 year) 6. Recent use of glucagon-like peptide-1 (GLP-1) agonists (within 28 weeks)

Interventions

DRUG

Bimekizumab regimen 1 iv

DRUG

Bimekizumab regimen 2 iv

DRUG

Bimekizumab regimen 3 sc

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

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Conditions

Psoriatic ArthritisAxial Spondyloarthritis

Locations

Pa0019 114

Peoria, Arizona 85381-5025

United States

Pa0019 127

Apple Valley, California 92307

United States

Pa0019 111

Covina, California 91722

United States

Pa0019 119

Fullerton, California 92835

United States

Pa0019 117

Riverside, California 92518

United States

Pa0019 125

San Leandro, California 94578

United States

Pa0019 126

Temecula, California 92592

United States

Pa0019 141

Upland, California 91786

United States

Pa0019 120

Whittier, California 90602

United States

Pa0019 128

Whittier, California 90602

United States

Pa0019 123

Fort Collins, Colorado 80528

United States

Pa0019 143

Ormond Beach, Florida 32174

United States

Pa0019 113

South Miami, Florida 33155

United States

Pa0019 133

Zephyrhills, Florida 33542

United States

Pa0019 132

Chicago, Illinois 60661

United States

Pa0019 134

Lansing, Michigan 48911

United States

Pa0019 140

West Long Branch, New Jersey 07764-1503

United States

Pa0019 131

Albuquerque, New Mexico 87102

United States

Pa0019 144

Vandalia, Ohio 45377

United States

Pa0019 115

Duncansville, Pennsylvania 16635

United States

Pa0019 142

Rock Hill, South Carolina 29732

United States

Pa0019 116

Jackson, Tennessee 38305

United States

Pa0019 138

Murfreesboro, Tennessee 37128

United States

Pa0019 129

Baytown, Texas 77521

United States

Pa0019 136

Colleyville, Texas 76034

United States

Pa0019 135

Mesquite, Texas 75150

United States

Pa0019 124

Plano, Texas 75075

United States

Pa0019 121

Bellevue, Washington 98004

United States

Pa0019 145

Spokane, Washington 99216

United States

Pa0019 130

Beckley, West Virginia 25801

United States

Pa0019 204

Lovech,

Bulgaria

Pa0019 205

Pleven,

Bulgaria

Pa0019 201

Plovdiv,

Bulgaria

Pa0019 202

Plovdiv,

Bulgaria

Pa0019 203

Plovdiv,

Bulgaria

Pa0019 705

Brno,

Czechia

Pa0019 703

Hlučín,

Czechia

Pa0019 704

Ostrava,

Czechia

Pa0019 702

Uherské Hradiště,

Czechia

Pa0019 305

Berlin,

Germany

Pa0019 301

Hamburg,

Germany

Pa0019 302

Ratingen,

Germany

Pa0019 306

Wetzlar,

Germany

Pa0019 407

Bialystok,

Poland

Pa0019 418

Bialystok,

Poland

Pa0019 404

Bytom,

Poland

Pa0019 401

Elblag,

Poland

Pa0019 412

Krakow,

Poland

Pa0019 402

Lodz,

Poland

Pa0019 410

Lublin,

Poland

Pa0019 413

Nowa Sól,

Poland

Pa0019 417

Olsztyn,

Poland

Pa0019 406

Poznan,

Poland

Pa0019 408

Poznan,

Poland

Pa0019 411

Poznan,

Poland

Pa0019 415

Płońsk,

Poland

Pa0019 416

Torun,

Poland

Pa0019 405

Warsaw,

Poland

Pa0019 409

Warsaw,

Poland

Pa0019 414

Warsaw,

Poland

Pa0019 420

Wroclaw,

Poland

Pa0019 601

Košice,

Slovakia

Pa0019 603

Piešťany,

Slovakia