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NCT07291024NARecruiting

A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

Mayo Clinic

Start Date

12/3/2025

Completion Date

1/1/2029

Summary

The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Age ≥ 18 years * Ischemic stroke ≥6 months prior to enrollment. * Post-stroke lower extremity impairment defined as gait velocity of less than 0.8 m/s on a 10-meter walk test * Provision of informed consent Exclusion Criteria: * Intracerebral Hemorrhage * Active or prior psychosis or substance abuse within two years. * Pre-stroke modified Rankin Scale (mRS) 3-5. * Unable to participate in in-clinic rehabilitation. * Preexisting neurological disorders affecting gait and mobility, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), dementia, major head trauma.

Interventions

OTHER

Vagus nerve stimulation (VNS) paired with mobility training

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Conditions

Ischemic Stroke

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States