Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States
Start Date
2/24/2026
Completion Date
4/24/2031
Summary
IMPAACT 2046/UPLIFT (Understanding Practices of Lactation and Infant Feeding decisions Together with women with HIV) is a multi-site, mixed-methods, observational cohort study. The purpose of the study is to explore infant feeding preferences, practices, and outcomes among mothers with HIV and their families in the United States. It will employ both qualitative and quantitative research methods to address existing knowledge gaps and to understand the clinical, behavioral, and social factors influencing infant feeding decisions. As part of the study's mixed method approach, a longitudinal cohort study of mothers and their infants will be established. The study also aims to pilot a national registry of breastfeeding women living with HIV in the United States.
Detailed Description
This is a convergent mixed-method, multisite study to identify factors in infant feeding decisions and explore infant feeding perspectives, preferences, practices and outcomes among women with HIV in the US. Feasibility and acceptability of developing a national registry of breastfeeding women with HIV in the US will also be assessed. The study sites will enroll women with HIV who are pregnant or postpartum (PPWH), healthcare providers (HCPs) and ancillary healthcare professionals (AHPs), other influential individuals who contribute to infant feeding decisions, and pilot registry testers. The study will be comprised of three core activities: * Core Activity 1: Will explore the multifaceted process of infant feeding decision-making, and describe clinical practice, and counseling approaches via in-depth interviews (IDIs) and surveys. IDIs will be completed with PPWH, influential people who contribute to infant feeding decisions, HCPs, and AHPs. HCPs and AHPs will also complete self-administered surveys, and site staff at each site will complete site-level surveys to inform a landscape analysis. * Core Activity 2: Will establish an observational prospective cohort of PPWH, and their liveborn infants, to examine current infant feeding practices and outcomes and their associated costs and cost benefits. * Core Activity 3: Will develop and pilot a national registry of breastfeeding women with HIV and assess its feasibility and acceptability among pilot registry testers.
Eligibility Criteria
Age Range: No minimum to No maximum
Interventions
No intervention provided in this study
Conditions
Locations
University of Southern California (CRS 5048)
Los Angeles, California 90089
United States
David Geffen School of Medicine at UCLA (CRS 5112)
Los Angeles, California 90095
United States
University California, San Diego (CRS 4601)
San Diego, California 92103
United States
University of Colorado, Denver (CRS 5052)
Aurora, Colorado 80045
United States
University of Florida (5051)
Jacksonville, Florida 32209
United States
Univ of Miami Pediatric/Perinatal HIV/AIDS (5127)
Miami, Florida 33136
United States
5030, Emory University School of Medicine Clinical Research Site
Atlanta, Georgia 30322
United States
Lurie Children's Hospital of Chicago (CRS 4001)
Chicago, Illinois 60614
United States
Johns Hopkins University (CRS 5092)
Baltimore, Maryland 21287
United States
Jacobi Med. Ctr. Bronx NICHD CRS (5013)
The Bronx, New York 10461
United States
St. Jude Childrens Research Hosp, Memphis (6501)
Memphis, Tennessee 38105
United States