Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology

Summary

This is a pilot study to evaluate the feasibility, image quality, and procedural utility of a novel spectral CT technique using Canon Medical's 4D CT system during image-guided interventional oncology procedures

Detailed Description

The aims of this study are: 1. Demonstrate the feasibility of acquisition and image quality of intra-arterial spectral CT images obtained during mapping arteriography prior to trans arterial radioembolization (TARE) for liver cancer treatment. 1. Assess the procedural utility of Spectral CT images as part of the TARE workflow, such as hepatopulmonary shunt fraction estimation, lesion identification, prediction of tumor: normal liver (T:N) dose ratio, and dose distribution 2. Investigate the feasibility, safety, and image quality of Spectral CT images obtained during tumor ablation. 2. Explore the feasibility of assessing physiologic tissue changes using Spectral CT (effective anatomic number maps) 1. During ablation with microwave, cryoablation, and irreversible electroporation in an ex vivo model 2. For image-guided tumor ablation, such as lesion identification, probe placement, and ablation monitoring.

Eligibility Criteria