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NCT07316166PHASE4Recruiting

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

Rhode Island Hospital

Start Date

1/20/2026

Completion Date

6/1/2027

Summary

The investigators are evaluating postoperative outcomes in patients undergoing hip replacement surgery performed with either spinal or general anesthesia, who also receive a suprainguinal fascia iliaca block using either perineural ropivacaine alone or ropivacaine combined with dexmedetomidine.

Detailed Description

Patients undergoing hip replacement surgery often receive a single-shot suprainguinal fascia iliaca block as a part of the primary anesthetic and multimodal postoperative analgesic strategy. However, the analgesic effect of a single-shot block typically diminishes after several hours and may be inconsistent beyond 24 hours. Adding dexmedetomidine, an alpha-2 agonist, to the local anesthetic has been shown to prolong block duration and reduce postoperative opioid requirements. Investigating its use in suprainguinal fascia iliaca blocks for total hip arthroplasty may clarify its clinical effectiveness. The investigators hypothesize that patients receiving ropivacaine with dexmedetomidine will have a significantly longer time to first analgesic request compared to those receiving ropivacaine alone.

Eligibility Criteria

Age Range: 18 years to 80 years

Inclusion Criteria: * Patients undergoing elective total hip arthroplasty * 18-80 years old * ASA 1-3 classifications Exclusion Criteria: * ASA classification of 4 or greater * Infection at the site of nerve blockade * Coagulopathy * Known allergy to study medications * Chronic opioid consumption (\>3 months) * Currently using lidocaine patches * Pre-existing neuropathy * A history of CVA * High grade atrioventricular block (cardiac conduction system impairment) * Organ dysfunction (cardiac failure, respiratory failure, end stage renal disease, hepatic dysfunction, hypoalbuminemia) * Morbid obesity (≥40 kg/m2) * Prior surgery in supra and/or infrainguinal region * Non-English-speaking participants

Interventions

DRUG

Dexmedetomidine

DRUG

Ropivacaine

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Conditions

Postoperative Pain Management

Locations

The Miriam Hospital

Providence, Rhode Island 02906

United States