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NCT07321886PHASE3Recruiting

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Eli Lilly and Company

Start Date

2/6/2026

Completion Date

7/1/2030

Summary

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Have Body Mass Index (BMI) at screening of the following: * 30 kilogram per square meter (kg/m2) OR * 27 kg/m2 with at least one of the following weight-related health conditions at screening: * high blood pressure * dyslipidemia * obstructive sleep apnea, or * heart disease * Have a stable body weight (\<5% body weight change) for 90 days prior to screening. * Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes or type 2 diabetes * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Interventions

DRUG

Eloralintide

DRUG

Placebo

Interested in This Trial?

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Conditions

ObesityOverweight

Locations

MFA Clinical Research

Tuscaloosa, Alabama 35405

United States

Headlands Research - Scottsdale

Scottsdale, Arizona 85260

United States

Neighborhood Healthcare Institute of Health

Escondido, California 92025

United States

Ark Clinical Research - Fountain Valley

Fountain Valley, California 92708

United States

Desert Oasis Healthcare Medical Group

Palm Springs, California 92262

United States

Peninsula Research Associates

Rolling Hills Estates, California 90274

United States

Care Access - Sacramento

Sacramento, California 95831

United States

Southern California Clinical Research

Santa Ana, California 92701

United States

University Clinical Investigators, Inc.

Tustin, California 92780

United States

Chase Medical Research, LLC

Waterbury, Connecticut 06708

United States

JEM Research Institute

Atlantis, Florida 33462

United States

BioMed Research & Medical Center

Miami, Florida 33156

United States

Adult Medicine of Lake County, Inc.

Mt. Dora, Florida 32757

United States

American Research Centers of Florida

Pembroke Pines, Florida 33027

United States

AHF Pensacola

Pensacola, Florida 32503

United States

IMA Clinical Research St. Petersburg

St. Petersburg, Florida 33704

United States

Teak Research Consults - Dunwoody

Dunwoody, Georgia 30338

United States

Teak Research Consults

Lawrenceville, Georgia 30043

United States

Clinical Research Atlanta

Stockbridge, Georgia 30281

United States

East-West Medical Research Institute

Honolulu, Hawaii 96814

United States

Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa 50266

United States

Cotton O'Neil Clinical Research Center

Topeka, Kansas 66606

United States

Care Access - Lake Charles (Bayou Pines)

Lake Charles, Louisiana 70601

United States

MedStar Good Samaritan Hospital

Baltimore, Maryland 21239

United States

MedStar Health Research Institute (MedStar Physician Based Research Network)

Hyattsville, Maryland 20782

United States

Care Access - Quincy

Quincy, Massachusetts 02169

United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan 48098

United States

AMR Clinical

Las Vegas, Nevada 89119

United States

IMA Clinical Research Warren

Warren Township, New Jersey 07059

United States

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico 87102

United States

Rochester Clinical Research, LLC

Rochester, New York 14609

United States

Monroe Biomedical Research

Monroe, North Carolina 28112

United States

Preferred Primary Care Physicians

Uniontown, Pennsylvania 15401

United States

Tribe Clinical Research, LLC

Greenville, South Carolina 29607

United States

Accellacare - Mt Pleasant

Mt. Pleasant, South Carolina 29464

United States

AMR Clinical

Nashville, Tennessee 37203

United States

The University of Texas Health Science Center at Houston

Bellaire, Texas 77401

United States

Velocity Clinical Research, Dallas

Dallas, Texas 75230

United States

UT Southwestern Medical Center

Dallas, Texas 75390-9302

United States

IMA Clinical Research San Antonio

San Antonio, Texas 78229

United States

AMR Clinical

Norfolk, Virginia 23502

United States

CONEXA Investigacion Clinica S.A.

Buenos Aires, 1012

Argentina

Cicemo Srl

Buenos Aires, 1424

Argentina

Cardiología Palermo

Buenos Aires, 1425

Argentina

Glenny Corp. S.A.

Buenos Aires, 1430

Argentina

CARDIAMET Investigaciones Médicas

Buenos Aires, C1014ACP

Argentina

Centro Médico Viamonte

Buenos Aires, C1120AAC

Argentina

Fundación Respirar

Buenos Aires, C1426ABP

Argentina

Instituto de Investigaciones Clínicas Córdoba

Córdoba, 5000

Argentina

INECO Neurociencias Oroño

Rosario, 2000

Argentina

Centro Modelo de Cardiología

San Miguel de Tucumán, 4000

Argentina

Emeritus Research

Botany, 2019

Australia

Core Research Group

Brisbane, 4064

Australia

Emeritus Research

Camberwell, 3124

Australia

Life Clinical Research

Ipswich, 4305

Australia

Paratus Clinical Research Central Coast

Kanwal, 2259

Australia

University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook

Meadowbrook, 4131

Australia

Momentum Sunshine

Melbourne, 3021

Australia

Paratus Clinical Research - Melbourne

Melbourne, 3070

Australia

AIM Research

Merewether, 2291

Australia

Fusion Clinical Research

Norwood, 5067

Australia

USC Clinical Trials Sunshine Coast

Sippy Downs, 4556

Australia

ANIMA Research

Diepenbeek, 3590

Belgium

Jessa Ziekenhuis

Hasselt, 3500

Belgium

Kormont

Kluisbergen, 9690

Belgium

Gezondheidshuis De Gloed

Machelen, 9870

Belgium

Chronos Pesquisa Clínica

Brasília, 72145-450

Brazil

Instituto de Pesquisa clinica de Campinas

Campinas, 13060-080

Brazil

Private Practice - Dr.Miguel N. Hissa

Fortaleza, 60430-350

Brazil

Centro de Pesquisa Clínica de Marília - CPCLIM

Marília, 17504-072

Brazil

Núcleo de Pesquisa Clínica do Rio Grande do Sul

Porto Alegre, 90430-001

Brazil

IBPClin - Instituto Brasil de Pesquisa Clínica

Rio de Janeiro, 20241-180

Brazil

Ruschel Medicina e Pesquisa Clínica

Rio de Janeiro, 22270-060

Brazil

CPCLIN

São Paulo, 01228-200

Brazil

CEPIC - Centro Paulista de Investigação Clínica

São Paulo, 04266-010

Brazil

CEDOES

Vitória, 29055450

Brazil

Integral Pesquisa e Ensino

Votuporanga, 15500-269

Brazil

Aggarwal and Associates Limited

Brampton, L6T 0G1

Canada

Med Trust Research

Courtice, L1E 2J5

Canada

Dawson Clinical Research Inc.

Guelph, N1H 1B1

Canada

Winterberry Research Inc.

Hamilton, L8J 0B6

Canada

The Wharton Medical Clinic Clinical Trials Inc

Hamilton, L8L 5G8

Canada

Alpha Recherche Clinique

Québec, G2J 0C4

Canada

ALPHA Recherche Clinique

Québec, G3K 2P8

Canada

Bluewater Clinical Research Group Inc.

Sarnia, N7T 4X3

Canada

Diex Recherche Inc. Division Trois-Rivieres

Trois-Rivières, G9A 4P3

Canada

Luhe Hospital

Beijing, 1001199

China

Beijing Pinggu District Hospital

Beijing, 101200

China

Sichuan Provincial People's Hospital

Chengdu, 610072

China

West China Hospital Sichuan University

Chengdu, 610041

China

Zhujiang Hospital

Guangzhou, 510280

China

The Second People's Hospital of Hefei

Hefei, 230011

China

Jinan Central Hospital

Jinan, 250013

China

The First Affiliated Hospital of Henan University of Science &Technology

Luoyang Shi, 471003

China

Jiangxi Provincial People's Hospital

Nanchang, 330006

China

Nanjing First Hospital

Nanjing, 210006

China

Jiangsu Province Official Hospital

Nanjing, 210008

China

Zhongda Hospital Southeast University

Nanjing, 210009

China

The Second Affiliated Hospital of Nanjing Medical University

Nanjing, 210011

China

Shanghai Sixth People's Hospital

Shanghai,

China

Zentrum fur klinische Forschung - Köln

Cologne, 51069

Germany

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, 01307

Germany

StudyPoint Duisburg

Duisburg, 47269

Germany

InnoDiab Forschung Gmbh

Essen, 45136

Germany

Medizentrum Essen Borbeck

Essen, 45355

Germany

Diabetes Zentrum Wilhelmsburg

Hamburg, 21109

Germany

Diabeteszentrum Hamburg West

Hamburg, 22607

Germany

AmBeNet GmbH

Leipzig, 04107

Germany

Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz

Lingen, 49808

Germany

BAG Drs. Med. Quist PartG

Mainz, 55128

Germany

CRS Clinical Research Services Mannheim

Mannheim, 68167

Germany

RED-Institut GmbH

Oldenburg, 23758

Germany

Praxis Sauter & Sauter & Vorbach

Wangen, 88239

Germany

Endolife Speciality Hospitals

Guntur, 522001

India

Gauhati Medical College and Hospital

Guwahati, 781032

India

Care Hospitals Hyderabad- Banjara Hills

Hyderabad, 500034

India

Mandya Institute Of Medical Sciences

Mandya, 571401

India

Topiwala National Medical College & B. Y. L. Nair Charitable Hospital

Mumbai, 400008

India

Mysore Medical College

Mysore, 570001

India

All India Institute of Medical Sciences (AIIMS) - Nagpur

Nagpur, 441108

India

Supe Heart & Diabetes Hospital and Research Centre

Nashik, 422002

India

Lifepoint Multispeciality Hospital

Pune, 411057

India

Prabhu Diabetes Multi-Speciality Centre

Trichy, 620001

India

Adachi Kyosai Hospital

Adachi-ku, 120-0022

Japan

Nihonbashi Sakura Clinic

Chūōku, 103-0025

Japan

Medical Corporation Chiseikai Tokyo Center Clinic

Chūōku, 103-0027

Japan

Tokyo-Eki Center-building Clinic

Chūōku, 103-0027

Japan

Boocs Clinic Fukuoka

Fukuoka, 812-0025

Japan

Patient First Clinic Ginza-Shimbashi

Minato, 105-0004

Japan

Kanno Naika

Mitaka, 181-0013

Japan

Medical Corporation Heishinkai OCROM Clinic

Suita-shi, 565-0853

Japan

Higashi Shinjuku Clinic

Tokyo, 169-0072

Japan

Zdrowie Osteo-Medic

Bialystok, 15-351

Poland

Legeartis - Poradnie Specjalistyczne

Bialystok, 15-404

Poland

Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

Krakow, 31-261

Poland

Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, 90-338

Poland

Gabinety TERPA

Lublin, 20-333

Poland

Ekamed

Lublin, 20-718

Poland

Centrum Zdrowia Metabolicznego Pawel Bogdanski

Poznan, 60-589

Poland

Pracownia Badań Klinicznych Salus

Wroclaw, 53-034

Poland

Samodzielny Publiczny Szpital Kliniczny nr 1 SUM

Zabrze, 41-800

Poland

Puerto Rico Health and Wellness Institute

Dorado, 00646

Puerto Rico

Wellness clinical Research Vega Baja

Vega Baja, 00693

Puerto Rico

Gachon University Gil Medical Center

Namdong-gu, 21565

South Korea

Konyang University Hospital

Seogu, 35365

South Korea

Seoul National University Bundang Hospital

Seongnam, 13620

South Korea

Seoul National University Hospital

Seoul, 03080

South Korea

Pusan National University Yangsan Hospital

Yangsan, 50612

South Korea

Chiayi Christian Hospital

Chiayi City, 600

Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807

Taiwan

Chang Gung Memorial Hospital at Kaohsiung

Kaohsiung Niao Sung Dist, 83301

Taiwan

National Taiwan University Hospital

Taipei, 10002

Taiwan

Taipei Veterans General Hospital

Taipei, 11217

Taiwan

Layton Medical Centre

Blackpool, FY3 7EN

United Kingdom

Bradford on Avon Health Centre

Bradford-on-Avon, BA15 1DQ

United Kingdom

Ashton Medical Group - Chapel House

Lancashire, OL6 6EW

United Kingdom

Royal Lancaster Infirmary

Lancaster, LA1 4RP

United Kingdom

Altnagelvin Area Hospital

Londonderry, BT47 6SB

United Kingdom

Bodyline Clinic - Openshaw

Manchester, M11 1AA

United Kingdom

Wansford Research Limited

Peterborough, PE8 6PL

United Kingdom

Abbeywell Surgery

Romsey, SO51 7QN

United Kingdom

Rame Group Practice

Torpoint, PL11 2TB

United Kingdom