NCT07325136PHASE1, PHASE2Recruiting
A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination Therapy in Participants With Relapsed/Refractory Small Cell Lung Cancer
Bristol-Myers Squibb
Start Date
2/3/2026
Completion Date
4/24/2029
Summary
The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Pumitamig in participants with Relapsed/Refractory Small Cell Lung Cancer
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria
* Participants must have histologically or cytologically documented relapsed/refractory small cell lung cancer (R/R-SCLC).
* Participants must have received at least 1 platinum-based chemotherapy regimen as per locally approved drug labels and institutional guidelines.
* In countries where standard of care first line systemic treatment includes platinum containing chemotherapy in combination with anti-PD-(L)1 therapy, it is required that participants have progressed on, are ineligible for or not have access to an anti-PD- (L)1 therapy.
Exclusion Criteria
* Participants must not have any untreated CNS metastases.
* Participants must not have an active, known or suspected autoimmune disease.
* Participants must not have had a prior organ or tissue allograft.
* Other protocol-defined Inclusion/Exclusion criteria apply.
Interventions
DRUG
BMS-986525
DRUG
Pumitamig
Conditions
Relapsed/Refractory Small Cell Lung Cancer
Locations
Karmanos Cancer Institute
Detroit, Michigan 48201
United States
Local Institution - 0026
Buffalo, New York 14263
United States
Duke Cancer Institute
Durham, North Carolina 27710
United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio 44106
United States
SCRI Oncology Partners
Nashville, Tennessee 37203
United States
Local Institution - 0028
Shanghai Shi, Shanghai Municipality 200120
China
Istituto Clinico Humanitas
Rozzano, Milano 20089
Italy
Local Institution - 0020
Hirakata, Osaka 573-1191
Japan
Local Institution - 0018
Chuo-ku, Tokyo 104-0045
Japan
Oncohelp Medical Center
Timișoara, Timiș County 300239
Romania
Local Institution - 0003
Craiova, 200347
Romania
Local Institution - 0009
Madrid, 28041
Spain