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NCT07325136PHASE1, PHASE2Recruiting

A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination Therapy in Participants With Relapsed/Refractory Small Cell Lung Cancer

Bristol-Myers Squibb

Start Date

2/3/2026

Completion Date

4/24/2029

Summary

The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Pumitamig in participants with Relapsed/Refractory Small Cell Lung Cancer

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria * Participants must have histologically or cytologically documented relapsed/refractory small cell lung cancer (R/R-SCLC). * Participants must have received at least 1 platinum-based chemotherapy regimen as per locally approved drug labels and institutional guidelines. * In countries where standard of care first line systemic treatment includes platinum containing chemotherapy in combination with anti-PD-(L)1 therapy, it is required that participants have progressed on, are ineligible for or not have access to an anti-PD- (L)1 therapy. Exclusion Criteria * Participants must not have any untreated CNS metastases. * Participants must not have an active, known or suspected autoimmune disease. * Participants must not have had a prior organ or tissue allograft. * Other protocol-defined Inclusion/Exclusion criteria apply.

Interventions

DRUG

BMS-986525

DRUG

Pumitamig

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Conditions

Relapsed/Refractory Small Cell Lung Cancer

Locations

Karmanos Cancer Institute

Detroit, Michigan 48201

United States

Local Institution - 0026

Buffalo, New York 14263

United States

Duke Cancer Institute

Durham, North Carolina 27710

United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio 44106

United States

SCRI Oncology Partners

Nashville, Tennessee 37203

United States

Local Institution - 0028

Shanghai Shi, Shanghai Municipality 200120

China

Istituto Clinico Humanitas

Rozzano, Milano 20089

Italy

Local Institution - 0020

Hirakata, Osaka 573-1191

Japan

Local Institution - 0018

Chuo-ku, Tokyo 104-0045

Japan

Oncohelp Medical Center

Timișoara, Timiș County 300239

Romania

Local Institution - 0003

Craiova, 200347

Romania

Local Institution - 0009

Madrid, 28041

Spain