Lot-to-lot Consistency Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From 2 Months of Age
Start Date
1/20/2026
Completion Date
5/29/2028
Summary
This is a phase 3 randomized, modified double-blind study whose purpose is to measure whether 3 lots of the investigational pneumococcal vaccine PCV21 can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) in a similar way (ie, same immune response) when they are given to infants aged from approximately 2 months (42 to 89 days) and are safe compared to a licensed 20-valent pneumococcal vaccine (20vPCV) (Prevnar 20™). The study duration per participant will be up to approximately 17 months. The study vaccines (either PCV21 or 20vPCV) will be administered at approximately 2, 4, 6 and 12 months of age. Cohort A will include randomization to three PCV21 formulation groups or one 20vPCV comparator group (Group 1-4, approximately 896 total participants), whereas Cohort B will include randomization to three PCV21 formulation groups only (Groups 1-3, approximately 1299 total participants). Routine pediatric vaccines will be given as per local recommendations. There will be 6 study visits: Visit (V)01, V02 separated from V01 by 60 days, V03 separated from V02 by 60 days, V04 separated from V03 by 30 days, V05 at 12 months of age, V06 separated from V05 by 30 days
Eligibility Criteria
Age Range: No minimum to No maximum
Interventions
PCV21 vaccine
20vPCV licensed vaccine
Conditions
Locations
Northwest Arkansas Pediatric Clinic- Site Number : 8400039
Fayetteville, Arkansas 72703
United States
Matrix Clinical Research - Huntington Park- Site Number : 8400029
Huntington Park, California 90255
United States
Community Clinical Research- Site Number : 8400030
Los Angeles, California 90008
United States
Matrix Clinical Research - Los Angeles- Site Number : 8400028
Los Angeles, California 90057
United States
PAS Research - Tampa- Site Number : 8400034
Tampa, Florida 33613
United States
Kentucky Pediatric Research- Site Number : 8400036
Bardstown, Kentucky 40004
United States
Michigan Institute of Research- Site Number : 8400004
Allen Park, Michigan 48101
United States
Tribe Clinical Research At Neighbors Pediatrics- Site Number : 8400008
Charleston, South Carolina 29407
United States
Parkside Pediatrics - Simpsonville- Site Number : 8400005
Simpsonville, South Carolina 29681
United States
Tribe Clinical Research - Spartanburg- Site Number : 8400026
Spartanburg, South Carolina 29301
United States
PAS Research - Children's Care Clinic- Site Number : 8400035
Edinburg, Texas 78539
United States
Pediatric Center - Richmond- Site Number : 8400038
Richmond, Texas 77469
United States
Rio Clinical Trials - Canyon View- Site Number : 8400031
Ogden, Utah 84404
United States
Investigational Site Number : 3400001
San Pedro Sula, 21104
Honduras
Investigational Site Number : 3400002
Tegucigalpa, 11101
Honduras
Investigational Site Number : 3400003
Tegucigalpa, 11101
Honduras
Investigational Site Number : 6300005
Guayama, 00786
Puerto Rico
Investigational Site Number : 6300006
San Juan, 00918
Puerto Rico
Investigational Site Number : 6300007
Trujillo Alto, 00976
Puerto Rico