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NCT07362017PHASE3Recruiting

Open Label Study to Investigate the Safety and Efficacy of Ponesimod in Moderate-to-Severe Chronic Plaque Psoriasis

Vanda Pharmaceuticals

Start Date

2/17/2026

Completion Date

12/1/2028

Summary

An open label study to investigate the safety and efficacy of ponesimod in participants with moderate-to-severe chronic plaque psoriasis

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria: * Male and female subjects aged 18-65 years, inclusive * BMI \>18 and \<40 * Minimum affected BSA of 10% * PASI score ≥ 12 * PGA ≥ 3 * Diagnosed with moderate-to-severe plaque psoriasis Exclusion Criteria: * Diagnosis of generalized erythrodermic, generalized pustular (von Zumbusch), guttate, or palmoplantar psoriasis * History of an allergic reaction or known and/or significant sensitivity to study drug

Interventions

DRUG

Ponesimod

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Conditions

Moderate-to-severe Chronic Plaque Psoriasis

Locations

Vanda Investigational Site

Glendale, Arizona 85308

United States

Vanda Investigational Site

Fremont, California 94538

United States

Vanda Investigational Site

Rochester, New York 14623

United States

Vanda Investigational Site

Spokane, Washington 99202

United States