UCSF Center for Genome Surgery Biobank and Registry

Inclusion Criteria: For initial screening and discussion at huddle call: * Male and female individuals of any age, including pregnant women and their fetuses at any gestational age. * Self-referred or referred through their provider to the UCSF Center for Genome surgery/Interventional Genomics Board for a condition that is genetic or suspected to be genetic in origin. * UCSF patient OR consents to allow for their case to be presented at the IGB huddle. For enrollment into registry or biobanking: * Any above participant that the IGB agrees would be appropriate for enrollment in the registry and biobanking portion of this protocol OR Any male or female family member of any age of someone enrolled in the registry and biobanking portion of this protocol. * Provides informed consent for participation in the registry and biobanking portion of the protocol. Exclusion Criteria: For initial screening and discussion at huddle call: * Individuals who have previously been discussed by the IGB and determined to not be appropriate to move forward into the registry and biobanking portion of the protocol, unless new information related to their case may change the initial assessment. * Individuals who are not impacted by a genetic or suspected genetic condition. For enrollment into registry or biobanking: -Any participant that the IGB agrees is inappropriate for enrollment in the registry and biobanking portion of this protocol.