Sex Differences in E-Cigarette Perception
Start Date
7/30/2026
Completion Date
4/1/2027
Summary
This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.
Detailed Description
The goal of this protocol is to investigate how sex differences in response to menthol and nicotine influence product preference and choice. In this proposal, participants will be exposed to menthol non-nicotine and nicotine containing e-cigarettes and product preference and choice will be examined in a paradigm where a menthol nicotine-containing e-cigarette is progressively more difficult to earn, and a menthol non-nicotine e-cigarette is available at a low, fixed cost. Additionally, it will be investigated how menthol e-cigarettes with and without nicotine impact reward, appeal, and sensory effects in an initial sampling session (secondary and exploratory outcomes).
Eligibility Criteria
Age Range: 21 years to 44 years
Interventions
Nicotine Level 1 (0mg/ml)
Nicotine Level 2 (36mg/ml)
Nicotine Level 3 (59mg/ml)
Conditions
Locations
Yale School of Medicine
New Haven, Connecticut 06473
United States