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NCT07404982PHASE2Recruiting

Reversal of Spinal Anesthesia Residual Motor Block Via Intrathecal Catheter

Beth Israel Deaconess Medical Center

Start Date

3/19/2026

Completion Date

12/1/2027

Summary

The purpose of this study is to determine the feasibility of administering a predetermined amount of normal saline into the intrathecal or subarachnoid space via a small spinal catheter to reduce or eliminate the effects of previously injected spinal anesthetic following lower extremity orthopedic surgery.

Detailed Description

This is a prospective, randomized, interventional study to assess the feasibility and effectiveness of administering normal saline into the intrathecal or subarachnoid space through a small gauge epidural catheter via a single spinal needle to reverse residual anesthesia following lower extremity orthopedic surgery. This method is adapted from observations in obstetric populations where saline administered via the spinal catheter reduced headaches. This study investigates whether orthopedic patients will also receive unique benefits. Research procedures overview: * Randomization to intervention or control arm, * Use of 6-inch BD 20-gauge Quincke spinal needle, through which a B. Braun Perifix 24-gauge polyurethane catheter * Administration of normal saline * Administration of post-operative survey while in the PACU * Medical record review and abstraction.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: 1. Patients having elective lower extremity joint replacement surgery 2. Patients \>18 years Exclusion Criteria: 1. Contraindications to spinal anesthesia (refusal, lumbar spinal hardware, spinal abnormalities) 2. Patient on anticoagulation not withheld 3. Patient receiving re-operation on the same joint 4. Prior intra-cranial bleeding 5. Patient's ASA status \>3 6. Non-English speaking 7. Bromage score of 6 at the time of first PACU assessment post-enrollment

Interventions

DRUG

Normal Saline 10 mL Injection

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Conditions

Joint Replacement Surgery

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts 02215

United States