NCT07424625PHASE4Recruiting

A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

Mayo Clinic

Start Date

9/14/2026

Completion Date

6/1/2028

Summary

The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.

Eligibility Criteria

Age Range: 21 years to No maximum

* Inclusion criteria * Cardiothoracic surgery with use of cardiopulmonary bypass * Presence of metabolic acidosis (defined as a base excess of \<-5) * Minnesota Research Authorization * Exclusion criteria * Non-cardiac surgery patients or cardiac surgery without cardiopulmonary bypass * Absence of metabolic acidosis (metabolic acidosis being defined as a base excess of \<-5) * Pregnant patients * Prisoners * Opt out of Minnesota Research Authorization

Interventions

DRUG

Sodium bicarbonate

DRUG

Tris-hydroxymethyl Aminomethane

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Conditions

Metabolic Acidosis

Locations

Mayo Clinic

Rochester, Minnesota 55901

United States