NCT07428187NARecruiting
Snacking Effects on the Brain Response to Foods and Satiety During Dieting
University of Colorado, Denver
Start Date
3/5/2026
Completion Date
3/31/2028
Summary
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
Eligibility Criteria
Age Range: 25 years to 45 years
Inclusion Criteria:
* 25-45 years old
* BMI at least 27 kg/m2
* Comfortable completing a weight-loss intervention\\
* Willing to consume a daily snack of either walnuts or pretzels
Exclusion Criteria:
* Nut or wheat allergy
* History of bariatric surgery
* Current eating disorder
* Current illicit substance use
* Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum
* Uncontrolled hypertension (\>160/100 mmHg)
* Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results
* Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment
* Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists)
* Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns)
* Neurological illnesses or injury that would be anticipated to affect MRI data
* Weight change greater than 10% within 3 months prior to study participation
* Currently participating in another weight-loss study
* Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan)
* MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs
Interventions
OTHER
Snack Type 1: Walnuts
OTHER
Snack Type 2: Pretzels
Conditions
Overweight/Obesity
Locations
University of Colorado Anschutz Medical Campus
Aurora, Colorado 80045
United States