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NCT07431853PHASE2RecruitingAccepts Healthy Volunteers

A Study to Learn About mRNA Vaccines Against Influenza in Adults

Pfizer

Start Date

2/23/2026

Completion Date

6/22/2027

Summary

The purpose of this study is to learn about safety in participants taking the study vaccine (mRNA-based vaccine) and the ability of the study vaccine to trigger the body's immune response, targeting the flu virus (influenza virus). This study is seeking healthy participants 18 years of age or older. All participants in this study will receive only 1 dose in their arm, to deliver one of the experimental flu vaccines or one of the approved flu vaccines used for comparison. Participants will take part in this study for about 6 months, and participants will need to visit the study site at least 3 times. A blood sample will be taken at each of the 3 planned study visits and a swab from inside the nose will be taken at the first study visit.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria • Healthy and medically stable participants who are determined by medical history, physical examination (if clinically required), and clinical judgment of the investigator to be eligible for inclusion in the study. Exclusion Criteria * Tested positive for influenza ≤5 months (150 days) prior to Visit 1 (Day 1). * Vaccination with any investigational or licensed influenza vaccine ≤5 months (150 days) before Visit 1 (Day 1). * Receipt of antiviral therapies for influenza (eg, Tamiflu) ≤5 months (150 days) prior to Visit 1 (Day 1).

Interventions

BIOLOGICAL

Vaccine Candidate #1

BIOLOGICAL

Vaccine Candidate #2

BIOLOGICAL

Vaccine Candidate #3

BIOLOGICAL

Vaccine Candidate #4

BIOLOGICAL

Vaccine Candidate #5

BIOLOGICAL

Vaccine Candidate #6

BIOLOGICAL

TIV1 or TIV2

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Conditions

Healthy Adults

Locations

AMR Clinical

Mobile, Alabama 36608

United States

Diablo Clinical Research, LLC d/b/a Flourish Research

Walnut Creek, California 94598

United States

Clinical Research Consulting, LLC

Milford, Connecticut 06460

United States

George Washington Medical Faculty Associates

Washington D.C., District of Columbia 20037

United States

Indago Research & Health Center, Inc

Hialeah, Florida 33012

United States

Palm Springs Community Health Center

Miami Lakes, Florida 33014

United States

Clinical Research Atlanta

Stockbridge, Georgia 30281

United States

East-West Medical Research Institute

Honolulu, Hawaii 96814

United States

AMR Clinical

Kansas City, Missouri 64114

United States

Rochester Clinical Research, LLC

Rochester, New York 14609

United States

DM Clinical Research - Philadelphia

Philadelphia, Pennsylvania 19107

United States

SMS Clinical Research LLC

Mesquite, Texas 75149

United States

DM Clinical Research

Tomball, Texas 77375

United States

J. Lewis Research, Inc. / Foothill Family Clinic

Salt Lake City, Utah 84109

United States

Charlottesville Medical Research Center, LLC

Charlottesville, Virginia 22911

United States