NCT07439614NARecruitingAccepts Healthy Volunteers

Comparison of Root Canal Desinfection Protocols

State University of New York at Buffalo

Start Date

4/1/2026

Completion Date

6/1/2027

Summary

Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis

Detailed Description

This study aims to evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis: Er,Cr:YSGG laser activated irrigation and ultrasonic activation using a piezoelectric ultrasonic device (Dentsply International Inc., York, PA, USA) and Irrisafe tip (Satelec/Acteon, Merignac, France), comparing the detection of bacteria before and after instrumentation. Secondary aims are to assess presence of bacteria before and after chemomechanical preparation using two microbiological methods: * ATP level analysis using the Endocator device * Quantitative PCR (qPCR) for total bacterial quantification.

Eligibility Criteria

Age Range: 18 years to 70 years

Inclusion Criteria: * Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up. * Molar teeth indicated for endodontic treatment. * Teeth with intact pulp-chamber walls (no extensive coronal destruction). * Necrotic pulp confirmed by pulp testing. * Clinical and radiographic evidence of asymptomatic apical periodontitis. Exclusion Criteria: * Immature teeth * Teeth with calcified or obliterated canals * Teeth with extensive coronal destruction * Teeth with previous endodontic treatment * Symptomatic apical periodontitis * Teeth with periodontal pockets greater than 4 mm * Patients who have received systemic antibiotics in the last 3 months * Patients with a history of diabetes or immune impairment * Pregnant patients

Interventions

DEVICE

Desinfection device

DEVICE

Analytical microbiological methods

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Conditions

Periapical Periodontitis

Locations

Advance Education in Endodontics Program

Buffalo, New York 14214

United States