A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Start Date
3/27/2026
Completion Date
6/30/2028
Summary
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Eligibility Criteria
Age Range: 50 years to No maximum
Interventions
Tiespectus
Aflibercept
Conditions
Locations
Research Network Arizona / Retina Macula Institute of Arizona
Scottsdale, Arizona 85255
United States
Retina Center of Arkansas
Fayetteville, Arkansas 72703
United States
Retina Partners of Northwest Arkansas, PLLC
Springdale, Arkansas 72764
United States
Global Research Management, Inc.
Glendale, California 91204
United States
Retinal Consultants Medical Group (Site 024)
Modesto, California 95356
United States
Retina Consultants of Southern California (Site 043)
Redlands, California 92374
United States
Retinal Consultants Medical Group (Site 020)
Sacramento, California 95825
United States
Retinal Consultants Medical Group (Site 022)
Sacramento, California 95841
United States
Florida Eye Clinic (Site 130)
Altamonte Springs, Florida 32701
United States
Retina Group of Florida (Site 070)
Fort Lauderdale, Florida 33308
United States
Vitreo Retinal Associates
Gainesville, Florida 32607
United States
Fort Lauderdale Eye Institute (Site 042)
Plantation, Florida 33324
United States
Retina Vitreous Associates of Florida (Site 049)
St. Petersburg, Florida 33711
United States
Southern Vitreoretinal Associates
Tallahassee, Florida 32308
United States
Retina Associates of Florida, LLC
Tampa, Florida 33609
United States
Retina Vitreous Associates of Florida
Tampa, Florida 33617
United States
Wildwood Clinical Research / Florida Retina Institute
Wildwood, Florida 34785
United States
Illinois Retina Associates
Oak Park, Illinois 60304
United States
Springfield Clinic
Springfield, Illinois 62703
United States
Associated Vitreoretinal and Uveitis Consultants
Carmel, Indiana 46032
United States
Cumberland Valley Retina Consultants (Site 007)
Hagerstown, Maryland 21740
United States
Foundation for Vision Research (Site 073)
Grand Rapids, Michigan 49546
United States
Mississippi Retina Associates (Site 084)
Madison, Mississippi 39110
United States
Mid Atlantic Retina
Cherry Hill, New Jersey 08034
United States
ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)
Hauppauge, New York 11788
United States
Retina Vitreous Surgeons of CNY, PC (Site 033)
Liverpool, New York 13088
United States
Piedmont Retina Specialists - Winston-Salem
Winston-Salem, North Carolina 27103
United States
Cincinnati Eye Institute (Site 133)
Cincinnati, Ohio 45242
United States
Tulsa Retina Consultants
Tulsa, Oklahoma 74114
United States
Retina Northwest, PC
Portland, Oregon 97221
United States
EyeHealth Northwest
Portland, Oregon 97225
United States
Mid Atlantic Retina (Site 050)
Bethlehem, Pennsylvania 18017
United States
Palmetto Retina Center
Aiken, South Carolina 29803
United States
Charleston Neuroscience Institute - Bluffton (Site 124)
Bluffton, South Carolina 29910
United States
Charleston Neuroscience Institute (Site 104)
Charleston, South Carolina 29414
United States
Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina
Mt. Pleasant, South Carolina 29464
United States
Charles Retina Institute
Germantown, Tennessee 38138
United States
Retina Research Institute of Texas (Site 010)
Abilene, Texas 79606
United States
Southwest Retina Specialists
Amarillo, Texas 79106
United States
Texas Retina Associates
Arlington, Texas 76012
United States
Austin Research Center for Retina
Austin, Texas 78705
United States
Austin Retina Associates (Site 012)
Austin, Texas 78705
United States
Retina & Vitreous of Texas
Bellaire, Texas 77401
United States
Texas Retina Associates
Dallas, Texas 75231
United States
Texas Retina (Site 037)
Plano, Texas 75075
United States
Retina Center of Texas
Southlake, Texas 76092
United States
Retina Consultants of Texas (Site 014)
The Woodlands, Texas 77384
United States
Strategic Clinical Research Group
Weatherford, Texas 76087
United States
Retina Associates of Utah
Salt Lake City, Utah 84107
United States
Piedmont Eye Center (Site 054)
Lynchburg, Virginia 24502
United States
Pacific Northwest Retina (Site 112)
Burlington, Washington 98233
United States
Spokane Eye Clinical Research (Site 075)
Spokane, Washington 99204
United States
Retina Consultants, PLLC
Charleston, West Virginia 25301
United States
Grupo Laser Vision (Rosario Eximer Laser Vision SA)
Rosario, Santa Fe Province S2000DLA
Argentina
Oftalmología Global (Centro Médico Oftalmología Global) (Site 304)
Rosario, Santa Fe Province S2000DSK
Argentina
Microcirugia Ocular Rosario (Site 310)
Rosario, Santa Fe Province S2000TC
Argentina
Centro de Ojos Quilmes
Buenos Aires, B1878KDF
Argentina
Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302)
Buenos Aires, C1023AAQ
Argentina
RSresearch (Site 308)
Buenos Aires, C1033AAW
Argentina
Instituto Oftalmologico de Buenos Aires SA (Site 306)
Buenos Aires, C1120AAN
Argentina
Centro Oftalmologico Dr Charles y Asociados (Site 300)
Buenos Aires, C1121ABB
Argentina
Centro de Ojos Loria SRL (Site 312)
Buenos Aires, CP1832
Argentina
Centro Oftalmológico Dr. Zas
Buenos Aires, PC1023
Argentina
Instituto Donato
Cdad. Autónoma de Buenos Aires, C1428
Argentina
Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305)
Córdoba, 5000
Argentina
Centro Privado de Ojos Romagosa SA (Site 307)
Córdoba, X5000AAI
Argentina
Centrovision Clinica Oftalmologica
Mendoza, 5500
Argentina
Oftar Centro De Oftalmología en Mendoza
Mendoza, 5500
Argentina
Centro de la Visión (Site 309)
Salta, A4400
Argentina
Instituto Zeman Bardeci (Site 311)
Salta, A4400
Argentina
Eye Clinic Albury Wodonga (Site 425)
Albury, 2640 NSW
Australia
Marsden Eye Specialists (Site 420)
Parramatta, 2150, NSW
Australia
Marsden Eye Specialists (Site 423)
Strathfield, 2135 NSW
Australia
Sydney Eye Hospital (Site 426)
Sydney, 2000 NSW
Australia
Sydney Retina Clinic and Day Surgery (Site 424)
Sydney, 2000, NSW
Australia
Barzilai Medical Center
Ashkelon, 7830604
Israel
Rambam Health Corporation (Site 706)
Haifa, 3109601
Israel
Carmel Medical Center (Site 704)
Haifa, 3436212
Israel
Hadassah Medical Center Opthalmology Department (Site 701)
Jerusalem, 9112001
Israel
Rabin Medical Center (Site 700)
Petah Tikva, 49100
Israel
Sheba Medical Center (Site 707)
Ramat Gan, 6265601
Israel
Kaplan Medical Center Ophthalmology Department (Site 705)
Rehovot, 7661005
Israel
Shamir Medical Center (Site 703)
Ẕerifin, 7033001
Israel
P.Stradins clinical university hospital
Riga, LV1002
Latvia
Clinica de Oftalmologia Barraquer
Barcelona, 08021
Spain
University Hospital Basel, Eye Clinic
Basel, CH-4031
Switzerland
Swiss Eye Institute and Berner Augenklinik
Bern, CH-3007
Switzerland
Vista Augenklinik Binningen
Binnigen, CH-4102
Switzerland
Stadtspital Zurich Triemli Forschungszentrum Augenklinik
Zurich, CH-8063
Switzerland
University Hospitals of Leicester NHS Trust (Site 209)
Leicester, LE1 5WW
United Kingdom
London North West University Healthcare NHS Trust (LNWH) (Site 201)
London, NW10 7NS
United Kingdom