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NCT07440225PHASE2, PHASE3Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

EyeBiotech Ltd.

Start Date

3/27/2026

Completion Date

6/30/2028

Summary

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Eligibility Criteria

Age Range: 50 years to No maximum

The main inclusion criteria include but are not limited to the following: * Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye) * The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment The main exclusion criteria include but are not limited to the following * Has uncontrolled blood pressure at screening * History of any prior macular laser photocoagulation in the study eye * History of uveitis in either eye * History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study * Has uncontrolled glaucoma in the study eye * Active retinal disease other than the condition under investigation in the study eye * Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

Interventions

DRUG

Tiespectus

DRUG

Aflibercept

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

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Conditions

Macular DegenerationAge-Related Macular DegenerationChoroidal NeovascularizationWet Macular Degeneration

Locations

Research Network Arizona / Retina Macula Institute of Arizona

Scottsdale, Arizona 85255

United States

Retina Center of Arkansas

Fayetteville, Arkansas 72703

United States

Retina Partners of Northwest Arkansas, PLLC

Springdale, Arkansas 72764

United States

Global Research Management, Inc.

Glendale, California 91204

United States

Retinal Consultants Medical Group (Site 024)

Modesto, California 95356

United States

Retina Consultants of Southern California (Site 043)

Redlands, California 92374

United States

Retinal Consultants Medical Group (Site 020)

Sacramento, California 95825

United States

Retinal Consultants Medical Group (Site 022)

Sacramento, California 95841

United States

Florida Eye Clinic (Site 130)

Altamonte Springs, Florida 32701

United States

Retina Group of Florida (Site 070)

Fort Lauderdale, Florida 33308

United States

Vitreo Retinal Associates

Gainesville, Florida 32607

United States

Fort Lauderdale Eye Institute (Site 042)

Plantation, Florida 33324

United States

Retina Vitreous Associates of Florida (Site 049)

St. Petersburg, Florida 33711

United States

Southern Vitreoretinal Associates

Tallahassee, Florida 32308

United States

Retina Associates of Florida, LLC

Tampa, Florida 33609

United States

Retina Vitreous Associates of Florida

Tampa, Florida 33617

United States

Wildwood Clinical Research / Florida Retina Institute

Wildwood, Florida 34785

United States

Illinois Retina Associates

Oak Park, Illinois 60304

United States

Springfield Clinic

Springfield, Illinois 62703

United States

Associated Vitreoretinal and Uveitis Consultants

Carmel, Indiana 46032

United States

Cumberland Valley Retina Consultants (Site 007)

Hagerstown, Maryland 21740

United States

Foundation for Vision Research (Site 073)

Grand Rapids, Michigan 49546

United States

Mississippi Retina Associates (Site 084)

Madison, Mississippi 39110

United States

Mid Atlantic Retina

Cherry Hill, New Jersey 08034

United States

ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)

Hauppauge, New York 11788

United States

Retina Vitreous Surgeons of CNY, PC (Site 033)

Liverpool, New York 13088

United States

Piedmont Retina Specialists - Winston-Salem

Winston-Salem, North Carolina 27103

United States

Cincinnati Eye Institute (Site 133)

Cincinnati, Ohio 45242

United States

Tulsa Retina Consultants

Tulsa, Oklahoma 74114

United States

Retina Northwest, PC

Portland, Oregon 97221

United States

EyeHealth Northwest

Portland, Oregon 97225

United States

Mid Atlantic Retina (Site 050)

Bethlehem, Pennsylvania 18017

United States

Palmetto Retina Center

Aiken, South Carolina 29803

United States

Charleston Neuroscience Institute - Bluffton (Site 124)

Bluffton, South Carolina 29910

United States

Charleston Neuroscience Institute (Site 104)

Charleston, South Carolina 29414

United States

Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina

Mt. Pleasant, South Carolina 29464

United States

Charles Retina Institute

Germantown, Tennessee 38138

United States

Retina Research Institute of Texas (Site 010)

Abilene, Texas 79606

United States

Southwest Retina Specialists

Amarillo, Texas 79106

United States

Texas Retina Associates

Arlington, Texas 76012

United States

Austin Research Center for Retina

Austin, Texas 78705

United States

Austin Retina Associates (Site 012)

Austin, Texas 78705

United States

Retina & Vitreous of Texas

Bellaire, Texas 77401

United States

Texas Retina Associates

Dallas, Texas 75231

United States

Texas Retina (Site 037)

Plano, Texas 75075

United States

Retina Center of Texas

Southlake, Texas 76092

United States

Retina Consultants of Texas (Site 014)

The Woodlands, Texas 77384

United States

Strategic Clinical Research Group

Weatherford, Texas 76087

United States

Retina Associates of Utah

Salt Lake City, Utah 84107

United States

Piedmont Eye Center (Site 054)

Lynchburg, Virginia 24502

United States

Pacific Northwest Retina (Site 112)

Burlington, Washington 98233

United States

Spokane Eye Clinical Research (Site 075)

Spokane, Washington 99204

United States

Retina Consultants, PLLC

Charleston, West Virginia 25301

United States

Grupo Laser Vision (Rosario Eximer Laser Vision SA)

Rosario, Santa Fe Province S2000DLA

Argentina

Oftalmología Global (Centro Médico Oftalmología Global) (Site 304)

Rosario, Santa Fe Province S2000DSK

Argentina

Microcirugia Ocular Rosario (Site 310)

Rosario, Santa Fe Province S2000TC

Argentina

Centro de Ojos Quilmes

Buenos Aires, B1878KDF

Argentina

Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302)

Buenos Aires, C1023AAQ

Argentina

RSresearch (Site 308)

Buenos Aires, C1033AAW

Argentina

Instituto Oftalmologico de Buenos Aires SA (Site 306)

Buenos Aires, C1120AAN

Argentina

Centro Oftalmologico Dr Charles y Asociados (Site 300)

Buenos Aires, C1121ABB

Argentina

Centro de Ojos Loria SRL (Site 312)

Buenos Aires, CP1832

Argentina

Centro Oftalmológico Dr. Zas

Buenos Aires, PC1023

Argentina

Instituto Donato

Cdad. Autónoma de Buenos Aires, C1428

Argentina

Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305)

Córdoba, 5000

Argentina

Centro Privado de Ojos Romagosa SA (Site 307)

Córdoba, X5000AAI

Argentina

Centrovision Clinica Oftalmologica

Mendoza, 5500

Argentina

Oftar Centro De Oftalmología en Mendoza

Mendoza, 5500

Argentina

Centro de la Visión (Site 309)

Salta, A4400

Argentina

Instituto Zeman Bardeci (Site 311)

Salta, A4400

Argentina

Eye Clinic Albury Wodonga (Site 425)

Albury, 2640 NSW

Australia

Marsden Eye Specialists (Site 420)

Parramatta, 2150, NSW

Australia

Marsden Eye Specialists (Site 423)

Strathfield, 2135 NSW

Australia

Sydney Eye Hospital (Site 426)

Sydney, 2000 NSW

Australia

Sydney Retina Clinic and Day Surgery (Site 424)

Sydney, 2000, NSW

Australia

Barzilai Medical Center

Ashkelon, 7830604

Israel

Rambam Health Corporation (Site 706)

Haifa, 3109601

Israel

Carmel Medical Center (Site 704)

Haifa, 3436212

Israel

Hadassah Medical Center Opthalmology Department (Site 701)

Jerusalem, 9112001

Israel

Rabin Medical Center (Site 700)

Petah Tikva, 49100

Israel

Sheba Medical Center (Site 707)

Ramat Gan, 6265601

Israel

Kaplan Medical Center Ophthalmology Department (Site 705)

Rehovot, 7661005

Israel

Shamir Medical Center (Site 703)

Ẕerifin, 7033001

Israel

P.Stradins clinical university hospital

Riga, LV1002

Latvia

Clinica de Oftalmologia Barraquer

Barcelona, 08021

Spain

University Hospital Basel, Eye Clinic

Basel, CH-4031

Switzerland

Swiss Eye Institute and Berner Augenklinik

Bern, CH-3007

Switzerland

Vista Augenklinik Binningen

Binnigen, CH-4102

Switzerland

Stadtspital Zurich Triemli Forschungszentrum Augenklinik

Zurich, CH-8063

Switzerland

University Hospitals of Leicester NHS Trust (Site 209)

Leicester, LE1 5WW

United Kingdom

London North West University Healthcare NHS Trust (LNWH) (Site 201)

London, NW10 7NS

United Kingdom