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NCT07447895NARecruiting

Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies

University of Cincinnati

Start Date

4/16/2026

Completion Date

4/16/2030

Summary

This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation therapy.

Detailed Description

This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation therapy. The objective is to determine the rate of fecal incontinence at 3 months after RT in women undergoing pelvic radiation for gynecologic malignancies. The primary endpoint of this study is the rate of fecal incontinence at 3 months after RT utilizing the EORTC-QLQ CX24 validated survey. A score of 1 or higher will be classified as having incontinence.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: 1. Participants must be female. 2. Patients must be 18 years old or older. 3. Any patient with invasive cervical cancer who is planned for definitive chemoradiation. 4. Plan to receive a minimum dose of 45Gy to pelvis per investigator. 5. Willing to undergo pelvic floor physical therapy. Exclusion Criteria: 1. Any previous therapeutic pelvic radiation. 2. Non-English speaking.

Interventions

PROCEDURE

Pelvic floor physical therapy

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Conditions

Cervical CancerRadiation Therapy ComplicationPelvic Floor Disorders

Locations

University of Cincinnati

Cincinnati, Ohio 45219

United States