NCT07449208Recruiting
Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak
Memorial Sloan Kettering Cancer Center
Start Date
2/25/2026
Completion Date
2/25/2029
Summary
The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Documentation of Disease
* Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy.
* Patients must also have risk factors for anastomotic leak:
* Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR
* Salvage esophagectomy OR
* Planned cervical anastomosis OR
* Two or more comorbidities:
* Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure.
* Definition of Disease
* Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above.
* Patients must be candidate and have agreed to receive gastric preconditioning procedure
* Prior Treatment
o There are no requirements with regard to prior treatment.
* Age ≥ 18
* ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)
Interventions
PROCEDURE
Esophagectomy
Conditions
Esophageal Malignant Neoplasm PrimaryAnastomotic Leak
Locations
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey 07920
United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey 07645
United States
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester (All protocol activities)
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York 10065
United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
Rockville Centre, New York 11553
United States