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NCT07449208Recruiting

Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak

Memorial Sloan Kettering Cancer Center

Start Date

2/25/2026

Completion Date

2/25/2029

Summary

The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Documentation of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy. * Patients must also have risk factors for anastomotic leak: * Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR * Salvage esophagectomy OR * Planned cervical anastomosis OR * Two or more comorbidities: * Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure. * Definition of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above. * Patients must be candidate and have agreed to receive gastric preconditioning procedure * Prior Treatment o There are no requirements with regard to prior treatment. * Age ≥ 18 * ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)

Interventions

PROCEDURE

Esophagectomy

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Conditions

Esophageal Malignant Neoplasm PrimaryAnastomotic Leak

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey 07920

United States

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey 07748

United States

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey 07645

United States

Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)

Commack, New York 11725

United States

Memorial Sloan Kettering Westchester (All protocol activities)

Harrison, New York 10604

United States

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York 10065

United States

Memorial Sloan Kettering Nassau (All Protocol Activities)

Rockville Centre, New York 11553

United States