NCT07451613PHASE1, PHASE2Recruiting

Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

Leslie Thompson

Start Date

4/6/2026

Completion Date

1/1/2031

Summary

The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.

Eligibility Criteria

Age Range: 18 years to 65 years

Please note this may not be a complete list of eligibility criteria. Inclusion Criteria: * Have decision-making capacity and be able to provide written informed consent. * Are between 18 to 65 years of age * Have genetically confirmed diagnosis of Huntington's Disease * Able to undergo MRI scans, tolerate neurosurgical procedure, blood draws and lumbar puncture. Exclusion Criteria: * Are pregnant * Test positive for human immunodeficiency virus (HIV), hepatitis C or chronic hepatitis B at Screening * Have an implanted deep brain stimulation device.

Interventions

BIOLOGICAL

hNSC-01

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Huntington Disease

Locations

University of California, Irvine

Irvine, California 92697

United States