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NCT07477704PHASE2Recruiting

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

Regeneron Pharmaceuticals

Start Date

6/17/2026

Completion Date

2/23/2027

Summary

This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels). The aim of the study is to see how safe and effective alirocumab is when given weekly to adult participants who have hypercholesterolemia. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug once a week * How much study drug is in the blood at different times

Eligibility Criteria

Age Range: 18 years to 80 years

Key Inclusion Criteria: 1\. Participant has elevated LDL-C level, as defined in the protocol Key Exclusion Criteria: 1. Participant plans to initiate or change dose of lipid-lowering therapy 2. Use of any PCSK9 inhibitors NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply

Interventions

DRUG

Alirocumab

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Conditions

Hypercholesterolemia

Locations

Pinnacle Research Group

Anniston, Alabama 36207

United States

Cullman Clinical Trials

Cullman, Alabama 35055

United States

Anaheim Clinical Trials

Anaheim, California 92801

United States

Cenexel CNS

Los Alamitos, California 90720

United States

Diablo Clinical Research - Flourish Research

Walnut Creek, California 94598

United States

Tampa Bay Medical Research

Clearwater, Florida 33761

United States

Southwest General Healthcare Center

Fort Myers, Florida 33907

United States

Precision Clinical Research

Sunrise, Florida 33351

United States

K2 Medical Research The Villages

The Villages, Florida 32159

United States

Center for Advanced Research and Education

Gainesville, Georgia 30501

United States

Balanced Life Health Care Solutions

Lawrenceville, Georgia 30046

United States

East-West Medical Research Institute

Honolulu, Hawaii 96814

United States

L-MARC Research Center

Louisville, Kentucky 40213

United States

Tandem Clinical Research

Marrero, Louisiana 70072

United States

Mercury Street Medical Group, PLLC

Butte, Montana 59701

United States

Velocity Clinical Research - Omaha

Omaha, Nebraska 68134

United States

Palm Research Center, Mountainview Medical Center

Las Vegas, Nevada 89128

United States

Velocity Clinical Research - Durham

Durham, North Carolina 27701

United States

Accellacare of Wilmington

Wilmington, North Carolina 28401

United States

Ohio Clinical Trials

Columbus, Ohio 43212

United States

AMR Norman

Norman, Oklahoma 73069

United States

Lynn Health Science Institute

Oklahoma City, Oklahoma 73112

United States

Velocity Clinical Research, Medford

Medford, Oregon 97504

United States

Altoona Center for Clinical Research

Duncansville, Pennsylvania 16635

United States

Tribe Clinical Research

Greenville, South Carolina 29607

United States

Coastal Carolina Research Center_North Charleston

North Charleston, South Carolina 29405

United States

Velocity Clinical Research Dallas

Dallas, Texas 75230

United States

Valley Institute of Research, Rockwood Medical Clinic

Fort Worth, Texas 76164

United States

Be Well Clinical Studies - Round Rock

Round Rock, Texas 78681

United States

Flourish Research - San Antonio Medical Trials

San Antonio, Texas 78229

United States

Endeavor Clinical Trials

San Antonio, Texas 78240

United States

Consano Clinical Research, LLC

Shavano Park, Texas 78231

United States

Charlottesville Medical Research

Charlottesville, Virginia 22911

United States

Rainier Clinical Research Center

Renton, Washington 98057

United States