NCT07495332NARecruiting
Siemens Biomarker Multi-modality
Duke University
Start Date
3/27/2026
Completion Date
5/1/2027
Summary
The purpose of this study is to see how well Photon Counting CT (PCCT) and ultrasound test results can find fat and scarring in the liver. They will be compared to MRI test results as the reference standard. Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study. They will also get an MRI, either on the same day or a different day, whichever is preferred. Participants will get an ultrasound on the same day as the MRI. If they have not had a hematocrit blood test in the past 24 hours, they will also receive one on the day of the CT scan.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Age of 18 years or older
* Has clinically indicated CT schedule including the liver (with contrast or with and without contrast)
* Patient eligible for MR imaging
* History of chronic diffuse liver disease, steatotic liver disease, and/ or liver fibrosis
* Capable of consent
Exclusion Criteria:
* Contraindications to any of the required imaging examinations
* BMI \> 45 (based on MRI scanner capacity)
Interventions
DIAGNOSTIC_TEST
Photon-counting CT (PCCT)
DIAGNOSTIC_TEST
Ultrasound
DIAGNOSTIC_TEST
Magnetic Resonance Imaging (MRI)
Conditions
Fatty LiverHepatic Steatosis
Locations
Duke University Medical Center
Durham, North Carolina 27710
United States