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NCT07496567PHASE2, PHASE3Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

EyeBiotech Ltd.

Start Date

4/15/2026

Completion Date

7/31/2028

Summary

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Eligibility Criteria

Age Range: 50 years to No maximum

The main inclusion criteria include but are not limited to the following: * Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye) * The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment The main exclusion criteria include but are not limited to the following * Has uncontrolled blood pressure at screening * History of any prior macular laser photocoagulation in the study eye * History of uveitis in either eye * History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study * Has uncontrolled glaucoma in the study eye * Active retinal disease other than the condition under investigation in the study eye * Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

Interventions

DRUG

Tiespectus

DRUG

Aflibercept

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

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Conditions

Macular DegenerationAge-Related Macular DegenerationChoroidal NeovascularizationWet Macular Degeneration

Locations

Associated Retina Consultants - Gilbert

Gilbert, Arizona 85259

United States

The Retina Partners

Encino, California 91436

United States

Northern California Retina Vitreous Associates Medical Group, Inc.

Mountain View, California 94040

United States

Retina Consultants of Southern Colorado

Colorado Springs, Colorado 80909

United States

RSC Research LLC

Denver, Colorado 80222

United States

Retina Consultants of Southern Colorado

Pueblo, Colorado 81008

United States

Connecticut Eye Consultants, P.C.

Danbury, Connecticut 06810

United States

Retina Consultants, P.C.

Manchester, Connecticut 06042

United States

Retina Group of New England

Waterford, Connecticut 06385

United States

Retina Group of Florida

Fort Myers, Florida 33912

United States

Florida Retina Institute

Orlando, Florida 32806

United States

Retina Group of Florida (Site 065)

Sarasota, Florida 34232

United States

Center for Retina and Macular Disease (Site 062)

Winter Haven, Florida 33880

United States

Illinois Retina Associates

Joliet, Illinois 60435

United States

University Retina & Macula Associates, P.C.

Lemont, Illinois 60439

United States

Wolfe Eye Clinic

West Des Moines, Iowa 50266

United States

Retina Associates, LLC

Lenexa, Kansas 66215

United States

Butchertown Clinical Trials

Louisville, Kentucky 40206

United States

Maine Eye Center (Site 097)

Portland, Maine 04101

United States

Mid Atlantic Retina Specialists

Hagerstown, Maryland 21740

United States

Retina Research Institute at New England Retina Consultants, PC

Springfield, Massachusetts 01107

United States

Retina Consultants of Minnesota

Edina, Minnesota 55435

United States

Envision Ocular, LLC

Bloomfield, New Jersey 07003

United States

Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY

Great Neck, New York 11021

United States

Retina Associates of Western NY, PC (Site 051)

Rochester, New York 14620

United States

Asheville Eye Associates, Retina Division (Site 077)

Asheville, North Carolina 28803

United States

NC Retina

Cary, North Carolina 27511

United States

Graystone Eye

Hickory, North Carolina 28602

United States

NC Retina Associates

Wake Forest, North Carolina 27587

United States

Retina Consultants, LLC

Salem, Oregon 97302

United States

Cascade Medical Research Institute, LLC

Springfield, Oregon 97477

United States

Erie Retina Research

Erie, Pennsylvania 16505

United States

Charleston Neuroscience Institute (Site 034)

Beaufort, South Carolina 29902

United States

Palmetto Retina Center

Florence, South Carolina 29501

United States

Charleston Neuroscience Institute

Ladson, South Carolina 29456

United States

Palmetto Retina Center

West Columbia, South Carolina 29169

United States

Southeastern Retina Associates

Hixson, Tennessee 37343

United States

Southeastern Retina Associates (Site 095)

Johnson City, Tennessee 37604

United States

Southeastern Retina Associates, P.C.

Knoxville, Tennessee 37922

United States

Tennessee Retina

Nashville, Tennessee 37203

United States

Retina Consultants of Texas

Bellaire, Texas 77401

United States

Texas Retina Associates

Fort Worth, Texas 76104

United States

Retina Consultants of Texas

Katy, Texas 77494

United States

Austin Retina Associates

Round Rock, Texas 78681

United States

Retina Consultants of Texas

San Antonio, Texas 78240

United States

Austin Retina Associates

San Marcos, Texas 78666

United States

Retina Consultants of Texas

Schertz, Texas 78154

United States

Salt Lake Retina

West Jordan, Utah 84088

United States

Vistar Eye Center (Site 129)

Roanoke, Virginia 24019

United States

Pacific Northwest Retina

Bellevue, Washington 98004

United States

IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia (Site 332)

São Paulo, 04038-032

Brazil

Clinica Oftalmologica del Caribe (COFCA)

Barranquilla, 080001 - Atlantico

Colombia

Fundacion Oftalmologica Nacional

Bogotá, 110231 - D.C.

Colombia

Clinica de Oftalmologia Sandiego

Medellín, 050021 - Antioquia

Colombia

Klaudians Hospital - Ophthalmology department

Mladá Boleslav, 293 01

Czechia

VISUS spol. s r.o.

Náchod, 54701

Czechia

Axon Clinical, s.r.o. (Site 400)

Prague, 150 00

Czechia

Astra Clinic.s.r.o.

Prague, 184 00

Czechia

Hopital Intercommunal De Creteil

Créteil, 94010

France

Budapest Retina Associates

Budapest, 1133

Hungary

AIBILI Azinhaga de Santa Comba

Coimbra, 3000-548

Portugal

Hospital General de Catalunya

Barcelona, 8195

Spain

Oftalvist

Burjassot -(Valencia), 46100

Spain