A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)
Start Date
5/3/2026
Completion Date
4/1/2031
Summary
Researchers are looking for new ways to treat 2 types of non-Hodgkin lymphoma (NHL) called follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). FL is a slow-growing type of NHL. DLBCL is a fast-growing type of NHL. NHL is a cancer in the lymphatic system that causes swollen lymph nodes. The lymphatic system is part of the immune system. In this study, researchers want to learn if MK-1045 can treat FL and DLBCL. MK-1045 is a study treatment that is an immunotherapy, which helps the immune system fight cancer. The goals of this study are to learn how safe MK-1045 is and if people tolerate it. Researchers also want to see if FL and DLBCL respond (the cancer gets smaller or goes away) to treatment.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
MK-1045
Conditions
Locations
Colorado Blood Cancer Institute ( Site 7000)
Denver, Colorado 80218
United States
SCRI Oncology Partners ( Site 0100)
Nashville, Tennessee 37203
United States
Instituto Alexander Fleming ( Site 1404)
Ciudad Autonoma de Buenos Aires, Buenos Aires C1426ANZ
Argentina
Sanatorio Nuestra Senora del Rosario ( Site 1403)
Rosario, Santa Fe Province 2001
Argentina
Beijing Cancer hospital ( Site 1701)
Beijing, Beijing Municipality 100142
China
Shaare Zedek Medical Center ( Site 0603)
Jerusalem, 9103102
Israel
Haddasah Medical Center ( Site 0600)
Jerusalem, 9112001
Israel
Sheba Medical Center ( Site 0601)
Ramat Gan, 5265601
Israel
Sourasky Medical Center. ( Site 0604)
Tel Aviv, 6423906
Israel
INOC - Istituto Nazionale Oncologico Candiolo ( Site 0701)
Candiolo, Piedmont 10060
Italy
Pratia MCM Krakow ( Site 0903)
Krakow, Lesser Poland Voivodeship 30-727
Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 0900)
Warsaw, Masovian Voivodeship 02-781
Poland
Pratia Onkologia Katowice ( Site 0902)
Katowice, Silesian Voivodeship 40-519
Poland
Institut Català d'Oncologia (ICO) - Badalona ( Site 1103)
Badalona, Barcelona 08916
Spain
Hospital Virgen de la Victoria ( Site 1104)
Málaga, Malaga 29010
Spain
Hospital Universitari Vall de Hebron ( Site 1102)
Barcelona, 08035
Spain
Hospital Universitario Gregorio Maranon ( Site 1101)
Madrid, 28007
Spain
Hospital Universitario 12 de Octubre ( Site 1105)
Madrid, 28041
Spain
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1000)
Ankara, 06230
Turkey (Türkiye)
Koç Üniversitesi Hastanesi ( Site 1001)
Istanbul, 34010
Turkey (Türkiye)
Derriford Hospital ( Site 1304)
Plymouth, Devon Pl6 8DH
United Kingdom
The Christie NHS Foundation Trust ( Site 1300)
Manchester, M20 4BX
United Kingdom