NCT07525219PHASE3Recruiting

Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen

Wake Forest University Health Sciences

Start Date

6/22/2026

Completion Date

7/1/2027

Summary

Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.

Detailed Description

Frame placement can be painful even with local numbing medicine. This study compares two oral medications-Suzetrigine (an FDA-approved (January 30, 2025) non-opioid, non-addictive medication used to treat moderate-to-severe acute pain in adults)) and acetaminophen (Tylenol)-to see which is more effective at reducing this pain. Both Tylenol and Suzetrigine are currently being used for pain prevention during head frame placement. This study is being conducted to determine if one offers greater relief than the other.

Eligibility Criteria

Age Range: 21 years to No maximum

Inclusion Criteria: * Patients scheduled for a standard of care procedure requiring a stereotactic head frame to be placed Exclusion Criteria: * Patients not scheduled for a standard of care procedure requiring a stereotactic head frame to be placed will not be approached

Interventions

DRUG

Suzetrigine

DRUG

acetaminophen

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Analgesic Efficacy

Locations

Wake Forest University Health Sciences

Winston-Salem, North Carolina 27157

United States