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NCT07526571NARecruitingAccepts Healthy Volunteers

GLOW Study: Effects of Triple Protein in Women

University of North Carolina, Chapel Hill

Start Date

4/1/2026

Completion Date

12/1/2026

Summary

This single-site, randomized, blinded, placebo-controlled study will evaluate whether 4 weeks of daily Triple Support Protein powder improves glycemic control and overall well-being in healthy women aged 30-60 years. Participants will undergo baseline testing (DXA, fasting blood, standardized meal test with 2-hour glucose and insulin sampling), complete one acute supervised dose, and then consume a daily supplement for 4 weeks. During the final 14 days, participants will wear a continuous glucose monitor. Outcomes include postprandial glucose AUC, insulin sensitivity, and body composition.

Detailed Description

Midlife women experience hormonal changes that can impair metabolic health, sleep, and cognition. Triple plant-based protein powder includes creatine and fiber aimed at glycemic control, muscle support, and satiety. Design: 40 participants randomized (1:1) to Triple Protein Support vs. matched placebo for 4 weeks, with acute and chronic phases, weekly check-ins. Assessments: Baseline and end-of-study DXA and bloods; standardized meal tests with 2-hour glucose/insulin sampling; Analysis: Mixed-model ANOVA for primary and secondary endpoints with α=0.05.

Eligibility Criteria

Age Range: 30 years to 60 years

Inclusion Criteria: * Females aged 30-60 years. * BMI 18.5-40 kg/m\^2. * Recreationally active (≥30 min/wk moderate intensity exercise). * Healthy and free from disease per health history questionnaire. * Willing to abstain from caffeine, tobacco, and alcohol for 24 hours before testing days. Exclusion Criteria: * Currently supplementing whey protein. * Pregnant or nursing. * Lactose intolerant. * Currently using creatine monohydrate. * Severe hearing or speech impairment or inability to speak English

Interventions

DIETARY_SUPPLEMENT

Triple protein support

DIETARY_SUPPLEMENT

Placebo

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Conditions

Healthy Women

Locations

Department of Exercise and Sport Science, Applied Physiology Laboratory

Chapel Hill, North Carolina 27713

United States