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NCT07536399PHASE3Recruiting

Biologic Augmentation of TMJ Arthroscopy Using BMAC

Weill Medical College of Cornell University

Start Date

5/1/2026

Completion Date

6/1/2028

Summary

The goal of this clinical trial is to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections in patients with pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment. The main question it aims to answer: Does BMAC injection reduce the amount of inflammation and structural damage in the TMJ? Researchers will compare BMAC injection to corticosteroid injections see if BMAC injection helps . Participants will : * Be randomized to receive either BMAC or CS injection during TMJ arthroscopy * Visit the clinic for 3 follow up visits over 6 months and answer questionnaires * have 2 MRIs of their jaw

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: 1. Participant is at least 18 years of age and not older than 75 years of age 2. Participant is willing and able to provide written informed consent to participant in this study 3. Participant has symptoms of TMJ arthralgia (pain) with significant temporomandibular joint pain and dysfunction despite at least 30 days of conservative therapy (NSAIDS, muscle relaxants, bite splints, PT, warm compresses, soft diet, etc.) 4. Participant has baseline pain of ≥30 on a 100mm visual analog scale (VAS) Exclusion Criteria: 1. Participant has not competed at least 30 days of conservative therapy 2. Participant was diagnosed with central or neuropathic pain disorder 3. Participant has a primary diagnosis of myofascial pain 4. Participant has fibromyalgia 5. Participant is pregnant or breastfeeding 6. Participant had traumatic injury to the masticatory muscles or temporomandibular joint within 12 months of screening 7. Participant who has the following contraindications to MRI: * Electrical implants such as cardiac pacemakers or perfusion pumps * Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the eye, or steel implants * History of seizures * Patients with GFR \< 15 ml/min/1.73m2 or who are on dialysis will be excluded from the study. * Allergy to contrast die

Interventions

BIOLOGICAL

Bone Marrow Aspirate Concentrate

DRUG

Corticosteroid (CS)

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Conditions

TMJ - Oral &Maxillofacial SurgeryOral and Maxillofacial ConditionsTMJ PainTMJ Arthralgia

Locations

Weill Cornell Medical College - NewYork-Presbyterian Hospital

New York, New York 10024

United States