A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Start Date
10/6/2026
Completion Date
3/31/2035
Summary
The main purpose of this study is to evaluate the efficacy of divarasib compared with investigator's choice of immunotherapy (pembrolizumab or nivolumab) or observation in participants with resected Kirsten rat sarcoma viral oncogene homolog glycine 12 to cysteine (KRAS G12C)-positive Stage II-IIIB NSCLC, regardless of tumor programmed death-ligand 1 (PD-L1) status, who have not achieved pathologic complete response (pCR) following neoadjuvant chemoimmunotherapy.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Divarasib
Pembrolizumab
Nivolumab
Conditions
Locations
Community Cancer Institute (CCI)
Clovis, California 93611
United States
Piedmont Cancer Institute, PC
Atlanta, Georgia 30318
United States
Profound Research, LLC
Farmington Hills, Michigan 48334
United States
Renown Regional Medical Center
Reno, Nevada 89502
United States
Cancer Care Specialists
Reno, Nevada 89511
United States
San Juan Oncology Associates
Farmington, New Mexico 87401
United States
Sanatorio de la Mujer
Rosario, Santa Fe Province S2000ORE
Argentina
Instituto Argentino de Diagnóstico y Tratamiento- IADT
Capital Federal, C1122AAL
Argentina
Hospital Britanico
Ciudad Autonoma Buenos Aires, C1280AEB
Argentina
Centro Oncologico Korben
Ciudad Autonoma Buenos Aires, C1426AGE
Argentina
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, C1430EGF
Argentina
Hospital Privado De Comunidad
Mar del Plata, B7602CBM
Argentina
Cenantron - Centro Avancado de Tratamento Oncologico
Belo Horizonte, Minas Gerais 30130-090
Brazil
Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul 90035-001
Brazil
Hospital Sao Lucas - PUCRS
Porto Alegre, Rio Grande do Sul 90610-000
Brazil
Clinica de Neoplasias Litoral
Itajaí, Santa Catarina 88301-220
Brazil
Beneficencia Portuguesa de Sao Paulo
São Paulo, 01321-00
Brazil
Jewish General Hospital
Montreal, Quebec H3T 1E2
Canada
Guangdong General Hospital
Guangzhou, 510030
China
Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo
Bogota, D.C., 110131
Colombia
Clinica ASTORGA
Medellín, 50010
Colombia
Attikon University General Hospital
Athens, 124 61
Greece
Athens Medical Center
Marousi, 151 25
Greece
Queen Mary Hospital
Hong Kong,
Hong Kong
Prince of Wales Hosp
Shatin,
Hong Kong
Ospedale P. Pederzoli Casa di cura Privata
Peschiera Del Garda (VR), Veneto 37019
Italy
Gifu University Hospital
Gifu, 501-1194
Japan
Kobe University Hospital
Hyōgo, 650-0017
Japan
Centrum Pulmonologii i Torakochirurgii
Bystra, 43-360
Poland
Uniwersyteckie Centrum Kliniczne, O?rodek Bada? Klinicznych Wczesnych Faz
Gda?sk, 80-214
Poland
?wi?tokrzyskie Centrum Onkologii Samodzielny Publiczny Zak?ad Opieki Zdrowotnej w Kielcach;Klinika Onkologii Klinicznej
Kielce, 25-734
Poland
Centro Clinico Champalimaud
Lisbon, 1400-038
Portugal
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggido 13620
South Korea
Pusan National University Hospital
Busan, 602-739
South Korea
Yeungnam University Medical Center
Daegu, 42415
South Korea
Chungnam National University Hospital
Daejeon, 35015
South Korea
Ajou University Medical Center
Gyeonggi-do, 16499
South Korea
Gachon University Gil Medical Center
Incheon, 21565
South Korea
Chonnam National University Hwasun Hospital
Jeollanam-do, 58128
South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Hospital de Basurto
Bilbao, Vizcaya 48013
Spain
Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, 15006
Spain
Hospital General Univ. de Alicante
Alicante, 03010
Spain
Hospital Universitario San Cecilio
Granada, 18016
Spain
Hospital Universitario Miguel Servet
Zaragoza, 50009
Spain