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NCT07594717Recruiting

Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

Prisma Health-Upstate

Start Date

11/12/2025

Completion Date

5/1/2026

Summary

This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) receiving buprenorphine treatment who currently use e-cigarettes. Participants will smell and rate 11 EC flavors based on appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal and reinforcing effects of ECs in this population. The goal is to identify EC flavors that may enhance the acceptability of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.

Detailed Description

This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) who are receiving buprenorphine treatment and currently use e-cigarettes. Participants will complete a brief session in which they will smell and rate 11 EC flavors based on their appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal, positive subjective effects, and reinforcing potential of EC flavors in this population. The goal of the study is to identify one or more EC flavors that may enhance the acceptability and reinforcing effects of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.

Eligibility Criteria

Age Range: 21 years to No maximum

Inclusion Criteria: * Adults aged 21 years or older. * Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days. * Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day. * Diagnosed with opioid use disorder (OUD). * Currently receiving buprenorphine treatment for OUD. Exclusion Criteria: \-

Interventions

DRUG

Sweet-cooling

DRUG

Sweet non-cooling EC flavor

DRUG

Tobacco flavor EC

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Conditions

Nicotine Use DisoderOpioid Use Disorder

Locations

Prisma Health Recovery Clinic-Greenville

Greenville, South Carolina 29605

United States